Eating disorders in pregnancy.

OBJECTIVE: To highlight a problem of eating disorders in pregnancy and the need for interdisciplinary cooperation in these cases. DESIGN: Case report. SETTING: Department of Gynecology and Obstetrics, 2nd Faculty of Medicine, University hospital Motol, Prague. CASE REPORT: We report the course of pregnancy in a 19-year-old woman with an atypical form of mental anorexia. The patient was repeatedly hospitalized for metabolic disruption. The pregnancy was finally terminated at the 27th week of pregnancy for fetal growth restriction of the fetus. CONCLUSION: Despite the frequent irregularities of the menstrual cycle in eating disorders, a spontaneous conception is possible. The prognosis of pregnancy is uncertain and may endanger the mother and fetus. Management of pregnant women with eating disorders requires the cooperation of a perinatologist, internist, nutritional therapist, psychiatrist or psychologist.

Distribution of subcutaneously administered inulin between blood and peripheral lymph in the rabbit.

In experiments on rabbit peripheral lymph, the contribution of the blood and lymphatic system to the whole-body distribution of inulin after subcutaneous administration has been investigated and the effects of hyaluronidase and of thermal stimulus at the administration site examined. Inulin concentrations in lymph exceeded plasma concentrations by more than 100-fold. At the end of the experiment (90 min) the amount of drug in the total lymph collected was about one-seventh the amount found in urine. The blood system, as a result of higher circulation at the administration site distributes inulin from the subcutis more rapidly than does lymph. Hyaluronidase did not influence inulin concentrations in blood and lymph but thermal stimulus significantly decreased both concentration and total distribution. The decrease resulted from a developed oedema and vasoconstriction in the skin and subcutis of the cannulated extremity.