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2.
Lymphology ; 50(3): 120-130, 2017.
Article in English | MEDLINE | ID: mdl-30234248

ABSTRACT

Lymphedema (LE) following lymph node dissection is a major problem for cancer patients, and radiation therapy, extended surgery, groin dissection, obesity, and older age are well-established risk factors of LE. We studied whether these risk factors are further associated with high volumes of postoperative drainage fluid after complete lymph node dissection (CLND) for melanoma metastases. Moreover, we examined whether a high amount of drainage fluid after sentinel lymph node biopsy (SLNB) can predict a high amount of drainage fluid after subsequent CLND. Using descriptive statistics and regression analyses, we analyzed the cumulative volumes of postoperative drainage fluid for 836 melanoma patients with lymph node excision in the axilla or groin. In multiple regression analyses, the well-established risk factors of LE, i.e., increased body mass index, older age, and ilioinguinal versus inguinal versus axillary dissection predicted a high drainage volume after CLND. Of note, a high drainage fluid volume after SLNB also predicted a high drainage volume after subsequent CLND. In patients with groin dissections, who are particularly susceptible to swelling, extended iliac dissection, age above 60, and a cumulative drainage volume of more than 100 ml in the preceding SLNB were predictors of the cumulative drainage volume. We find that common risk factors predict the volume of postoperative drainage fluid after CLND and postoperative LE. Further, high postoperative drainage volume may therefore function as a potential early predictor of LE following CLND.

3.
J Eur Acad Dermatol Venereol ; 31(7): 1208-1213, 2017 Jul.
Article in English | MEDLINE | ID: mdl-27699880

ABSTRACT

BACKGROUND: Narrowband (TL-01) UVB phototherapy (UVB nb) is effective in treating inflammatory skin disease. The addition of UVA is traditionally advocated to reduce pruritus, but lacks evidence for this recommendation. OBJECTIVES: The aim of this study was to assess the effect of UVB nb and UVA phototherapy in combination compared against UVB nb monotherapy on pruritus, disease activity and quality of life. METHODS: In this double-blind randomized clinical trial, 53 patients suffering from inflammatory skin diseases with pronounced itching (Visual Analogue Scale (VAS) for pruritus ≥5) were randomized into two treatment groups. One group received UVB nb (311 nm) phototherapy alone and another group received a combination of UVB nb and UVA (320-400 nm) phototherapy. UV therapy was performed three times per week over 16 weeks. Pruritus (VAS and 5-D itch score), disease activity and quality of life (Dermatology Life Quality Index, DLQI) were assessed at baseline and weeks 4, 8, 12 and 16. RESULTS: In both treatment groups, there was a reduction in pruritus scores, disease activity and DLQI. No difference in pruritus score, disease activity and quality of life could be detected between the group receiving UVB nb alone and those receiving UVB nb combined with UVA. CONCLUSIONS: Phototherapy with UVB nb alone, and UVB nb combined with UVA are equally effective in treating inflammatory skin disease and indifferent in reducing disease-associated pruritus. Given this non-inferiority for UVB nb monotherapy, the recommendation of adding UVA to UVB nb phototherapy for pruritic inflammatory skin disease should be abandoned.


Subject(s)
Dermatitis/radiotherapy , Phototherapy , Ultraviolet Rays , Adult , Aged , Aged, 80 and over , Dermatitis/complications , Double-Blind Method , Female , Humans , Male , Middle Aged , Pruritus/etiology , Pruritus/radiotherapy , Quality of Life , Young Adult
5.
Zentralbl Chir ; 139 Suppl 2: e83-9, 2014 Dec.
Article in German | MEDLINE | ID: mdl-22511022

ABSTRACT

BACKGROUND: With respect to survival and local disease control, the adequate extent of lymph node dissection for melanoma metastasis to the groin is controversial. Since the methods for accurate quantification of leg oedemas are not well standardised, it remains also unclear whether the iliac part of a radical ilioinguinal lymph node dissection contributes to postoperative lymphoedema. PATIENTS AND METHODS: Using a questionnaire and clinical examinations, we prospectively studied 65 persons for the presence of leg swellings (11 with inguinal lymph node dissection (sCLND), 23 with ilioinguinal dissection (rCLND), and 31 without nodal surgery and without signs of venous insufficiency). Exact volumetry of the legs was performed using the Image 3 D method. RESULTS: The mean interval between the lymphadenectomy and the examination for swellings was 24 ±â€†30 months. Compared with sCLND, the amount of postoperative drainage fluid was significantly higher after rCLND (1960 ±â€†1390 mL versus (vs.) 898 ±â€†578 mL). Patients with rCLND perceived more frequently leg swellings (83 % vs. 55 %, p = 0.09), however, also 23 % of the control persons perceived leg swellings. Clinical signs of swelling were found slightly more frequently in the rCLND group (52 % vs. 45 %). After rCLND, the gain in volume of the ipsilateral thigh was significantly higher than after sCLND (7.01 ±â€†4.83 % vs. 1.29 ±â€†6.12 %, p = 0.01). Patients with rCLND more frequently needed manual lymph drainage (70 % vs. 45 %). In the control persons, the volumes of the right (mostly dominant) and the left legs did not differ significantly. CONCLUSIONS: Our results suggest that the iliac part of an ilioinguinal lymph node dissection significantly contributes to lymphoedema. Because of the multitude of reasons for swellings of the lower leg, volumetry of the thigh seems to be most adequate for quantifying the amount of postoperative lymphoedema.


Subject(s)
Image Interpretation, Computer-Assisted , Imaging, Three-Dimensional , Inguinal Canal/surgery , Linear Energy Transfer , Lymph Node Excision , Lymphatic Metastasis/pathology , Lymphedema/diagnosis , Melanoma/secondary , Melanoma/surgery , Postoperative Complications/diagnosis , Skin Neoplasms/surgery , Video Recording , Adult , Aged , Aged, 80 and over , Diagnosis, Differential , Female , Humans , Inguinal Canal/pathology , Male , Melanoma/pathology , Middle Aged , Skin Neoplasms/pathology , Venous Insufficiency/diagnosis , Young Adult
6.
J Acoust Soc Am ; 132(2): EL88-94, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22894321

ABSTRACT

Underwater and in-air noise evaluations were completed in performance pool systems at Georgia Aquarium under normal operating conditions and with performance sound tracks playing. Ambient sound pressure levels at in-pool locations, with corresponding vibration measures from life support system (LSS) pumps, were measured in operating configurations, from shut down to full operation. Results indicate noise levels in the low frequency ranges below 100 Hz were the highest produced by the LSS relative to species hearing thresholds. The LSS had an acoustic impact of about 10 dB at frequencies up to 700 Hz, with a 20 dB re 1 µPa impact above 1000 Hz.


Subject(s)
Bottle-Nosed Dolphin/physiology , Environment, Controlled , Facility Design and Construction , Hearing , Life Support Systems , Noise , Vibration , Water , Acoustic Stimulation , Animals , Auditory Pathways/physiology , Auditory Threshold , Environmental Monitoring/methods , Equipment Design , Georgia , Noise/adverse effects , Pressure , Signal Processing, Computer-Assisted , Sound Spectrography
7.
J Eur Acad Dermatol Venereol ; 25(12): 1432-9, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21392126

ABSTRACT

BACKGROUND: Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. OBJECTIVES: We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. PATIENTS AND METHODS: A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post-thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. RESULTS: The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). CONCLUSION: Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations.


Subject(s)
Leg Ulcer/complications , Thrombophilia/etiology , Varicose Ulcer/complications , Aged , Aged, 80 and over , Chronic Disease , Cohort Studies , Female , Humans , Male , Middle Aged
9.
Hautarzt ; 57(5): 423-7, 2006 May.
Article in German | MEDLINE | ID: mdl-16408219

ABSTRACT

BACKGROUND: Loss of appetite and nausea can reduce the quality of life of patients with malignant melanoma and liver metastases. Often established antiemetic drugs fail to bring relief. Tetrahydrocannabinol (THC, Marinol), which is the active agent of Indian hemp, has been used successfully in this situation for other malignant tumors. PATIENTS AND METHODS: We treated 7 patients with hematogenous metastatic melanoma and liver metastases suffering from extensive loss of appetite and nausea supportively with dronabinol (Marinol. All of these patients had previously received standard antiemetic therapy without adequate relief. Dronabinol is a synthetic Delta-tetrahydrocannabinol. The drug was administered in capsule form. We evaluated the palliative effects of dronabinol with a special patient evaluation form, which was filled out at the beginning of the therapy and again after 4 weeks. RESULTS: The majority of patients described a significant increase in appetite and decrease in nausea. These effects remained for some weeks, but then decreased as metastases progressed and the general condition worsened. All of the patients experienced slight to moderate dizziness, but it was not sufficiently troubling to cause interruption or termination of therapy. CONCLUSION: Loss of appetite and nausea due to liver metastases of malignant melanoma can be treated in individual cases supportively with Dronabinol.


Subject(s)
Dronabinol/therapeutic use , Feeding and Eating Disorders/prevention & control , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Melanoma/drug therapy , Melanoma/secondary , Nausea/prevention & control , Adult , Aged , Analgesics, Non-Narcotic/therapeutic use , Chemotherapy, Adjuvant/methods , Feeding and Eating Disorders/etiology , Female , Humans , Liver Neoplasms/complications , Male , Middle Aged , Nausea/etiology , Palliative Care/methods , Quality of Life , Skin Neoplasms/drug therapy , Treatment Outcome
10.
Hautarzt ; 57(7): 625-7, 2006 Jul.
Article in German | MEDLINE | ID: mdl-16049702

ABSTRACT

Leiomyosarcomas are derived from smooth muscles and only rarely involve the skin. A 73-year-old male presented with progressive tumor painful on the chest which had been present for 3 years and was tender to palpation, a finding more often associated with benign leiomyomas. immunohistochemical staining demonstrated multiple nerve fibers entrapped by atypical myofibrils, perhaps explaining the tenderness. Since 1996, we have excised five painless cutaneous leiomyosarcomas, in which entrapped nerves could not be demonstrated.


Subject(s)
Leiomyosarcoma/diagnosis , Pain/etiology , Skin Neoplasms/diagnosis , Aged , Biopsy , Diagnosis, Differential , Humans , Leiomyosarcoma/complications , Leiomyosarcoma/pathology , Leiomyosarcoma/surgery , Male , Palpation , Skin/pathology , Skin Neoplasms/complications , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Thorax
11.
Eur J Cancer ; 41(4): 531-8, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15737557

ABSTRACT

With regard to malignant melanoma, the impact of lymph node surgery on the development of loco-regional cutaneous metastases (LCM) has not yet been adequately addressed. However, this aspect is of interest, since sentinel lymphonodectomy (SLNE) has been suspected of causing LCM by inducing entrapment of melanoma cells. We analysed 244 patients with SLNE and compared the data with 199 patients treated with delayed lymph node dissection (DLND) for clinically palpable metastases. Analysis of both groups commenced at the time of excision of the primary tumour, using the Kaplan-Meier method. LCM that appeared as a first recurrence, as well as the overall probability of developing LCM, were recorded. For sentinel-negative patients with a primary melanoma >1mm thick, the 5-year probability of developing LCM as a first recurrence was 6.9 +/- 0.02% (+/-standard error of the mean (SEM)). The probability was 17.6 +/- 0.03% in the DLND group. Comparing the two node-positive subgroups, the probability of developing LCM as a first recurrence was significantly higher in patients with positive SLNE (27.3 +/- 0.05%, P = 0.03). However, the 5-year overall probability of developing LCM did not differ significantly in the node-positive groups (33.3% in the DLND group vs. 33.7% in patients with positive sentinel lymph nodes (SLNs)). Since early excision of lymphatic metastases by SLNE avoids nodal recurrences, thereby prolonging the recurrence-free interval, the chance of LCM to manifest as a first recurrence should inevitably increase. However, the overall in-transit probability is not increased after SLNE.


Subject(s)
Melanoma/surgery , Skin Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Chemotherapy, Adjuvant , Disease-Free Survival , Female , Humans , Lymph Node Excision/methods , Lymphatic Metastasis , Male , Melanoma/drug therapy , Melanoma/secondary , Middle Aged , Prognosis , Risk Factors , Sentinel Lymph Node Biopsy , Skin Neoplasms/drug therapy
13.
Eur J Cancer ; 40(2): 212-8, 2004 Jan.
Article in English | MEDLINE | ID: mdl-14728935

ABSTRACT

Early versus delayed excision of lymph node metastases is still being assessed in malignant melanoma. In the present retrospective, multicentre study, the outcome of 314 patients with positive sentinel lymphonodectomy (SLNE) was compared with the outcome of 623 patients with delayed lymph node dissection (DLND) of clinically enlarged lymph node metastases. In order to avoid the lead-time bias, survival was generally calculated from the excision of the primary tumour. Survival curves were constructed using the Kaplan-Meier product-limit estimate. Cox's proportional hazards model was used to perform a multivariate analysis of factors related to overall survival. Compared with SLNE and early performed complete lymph node dissection, DLND yielded a significantly higher number of lymph node metastases. Median and mean tumour thickness were nearly identical in the two therapy groups. The estimated 3-year overall survival rate was 80.1+/-2.8% (+/-standard error of the mean (SEM)) in patients with positive SLNs, and 67.6+/-1.9% in patients with DLND (5-year survival rates 62.5+/-5.5 and 50.2+/-5.4%, respectively). The difference between the two survival curves was statistically significant (P=0.002). Using multifactorial analysis, SLNE (P=0.000052), American Joint Committee on Cancer (AJCC) Breslow thickness category (P<0.000001), age (P=0.01) and gender (P=0.028) were independent predictors of overall survival. The location of the primary tumour (P=0.59) was non-significant. Considering only those centres with sufficient data for epidermal ulceration, this risk factor was also significant. In cutaneous malignant melanoma, early excision of lymphatic metastases, directed by the sentinel node procedure, provides a highly significant overall survival benefit.


Subject(s)
Lymph Node Excision , Melanoma/surgery , Skin Neoplasms/surgery , Female , Humans , Lymphatic Metastasis , Male , Melanoma/pathology , Prognosis , Retrospective Studies , Sentinel Lymph Node Biopsy/methods , Skin Neoplasms/pathology , Survival Analysis , Time Factors
14.
Dermatology ; 207(1): 72-6, 2003.
Article in English | MEDLINE | ID: mdl-12835555

ABSTRACT

The Schimmelpenning-Feuerstein-Mims syndrome (SFM syndrome) is a rare and variable multisystem defect consisting of congenital, extensive linear nevus sebaceus and associated abnormalities in different neuroectodermal organ systems. We present the history of a 52-year-old female patient with disproportionate hyposomia and asymmetric constitution. From birth she suffered from a right-sided, extensive nevus sebaceus following Blaschko's lines extending on the scalp, neck, right arm and trunk. At the age of 5 years, she developed a generalized growth retardation, along with deformations of bones. At the age of 11, hypophosphatemic rickets was diagnosed causing this growth retardation. Moreover, the patient developed a precocious puberty at the age of 9 years. When we saw the patient 40 years after the diagnosis had been made, phosphaturia had returned to normal. Specific therapy of hypophosphatemic rickets is straightforward and efficient in preventing late complications like growth retardation. We suggest to conduct appropriate laboratory tests in early childhood in patients with an extensive systematized sebaceous nevus or with additional signs of growth retardation or skeletal involvement, in order to exclude hypophosphatemic rickets associated with SFM syndrome.


Subject(s)
Abnormalities, Multiple/diagnosis , Hypophosphatemia, Familial/diagnosis , Intellectual Disability/diagnosis , Nevus, Pigmented/diagnosis , Skin Neoplasms/diagnosis , Female , Humans , Hypophosphatemia, Familial/complications , Intellectual Disability/complications , Middle Aged , Nevus, Pigmented/complications , Prognosis , Risk Assessment , Skin Neoplasms/complications , Syndrome
15.
Melanoma Res ; 13(3): 299-302, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12777986

ABSTRACT

The anti-melanoma activity of vindesine as a single or polychemotherapeutic agent has been reported previously in adjuvant and first-line melanoma treatment. In this study, we investigated the usefulness of vindesine monotherapy as salvage therapy in stage IV melanoma patients after failure of other chemotherapies. Thirteen patients with progressive disease were treated with 3 mg/m2 vindesine every 2 weeks (median age, 61 years). Previous systemic treatment consisted of polychemotherapy or combined chemo-immunotherapy. All 13 patients suffered from visceral metastases (three lung, one liver, one adrenal gland and eight multiple visceral metastases). A median of three vindesine treatments was administered. Despite the various pre-treatments, the toxicity of vindesine was mild. In all 13 patients, vindesine treatment was stopped due to disease progression. The median survival after primary tumour diagnosis was 42 months (8-151 months), the survival after entering stage IV was 11 months (3-35 months), and the survival after starting vindesine therapy was 4 months (1-22 months). We conclude that vindesine monotherapy is ineffective in stage IV melanoma patients previously treated with other chemotherapeutic agents.


Subject(s)
Antineoplastic Agents, Phytogenic/therapeutic use , Melanoma/drug therapy , Melanoma/pathology , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Vindesine/therapeutic use , Adult , Aged , Alopecia/chemically induced , Antineoplastic Agents, Phytogenic/adverse effects , Disease-Free Survival , Female , Hematologic Diseases/chemically induced , Humans , Male , Melanoma/secondary , Middle Aged , Neoplasm Staging , Salvage Therapy , Treatment Outcome
16.
Hautarzt ; 54(4): 342-7, 2003 Apr.
Article in German | MEDLINE | ID: mdl-12669206

ABSTRACT

BACKGROUND AND OBJECTIVE: The objective of the study was to evaluate the use of a medical surgical zipper (Medizip) for wound closure under tension in comparison to conventional cutaneous sutures. The surgical zipper is supposed to reduce wound tension by approximating of the wound edges via epidermal traction. PATIENTS/METHODS: This prospective study included patients with a wound diameter of more than 1 cm. 45 patients were treated with the surgical zipper, 38 were randomized into a control group with conventional wound closure. Scars were assessed after 6-18 months focusing on aesthetic and functional aspects. RESULTS: The average length of the scars in both groups was 9 cm, but after a observation time of at least 6 month, there were differences in the width of the scars. The group with the surgical zipper showed significantly thinner scars (2.74 mm versus 4.24 mm, p=0.0008). Only 17% of the Medizip patients developed unaesthetic rope ladder-like scars versus 65% in the control group. This observation was statistically significant (p<0.0001). CONCLUSIONS: Wound stabilization by approximation of the wound edges via surgical zipper results in improved scar formation in wounds with moderate tension. Using the Medizip trade mark in wounds under heavy tension is not recommended because of the possible development of to tension bullae under the zipper.


Subject(s)
Cicatrix , Dermatologic Surgical Procedures , Suture Techniques/instrumentation , Wounds and Injuries/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Child , Cicatrix/pathology , Data Interpretation, Statistical , Follow-Up Studies , Humans , Middle Aged , Prospective Studies , Skin/injuries , Time Factors
17.
Eur J Cancer ; 39(2): 175-83, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12509949

ABSTRACT

To date, there are no reliable criteria to identify those patients with melanoma-infiltrated sentinel lymph nodes (SLNs) of the groin who might benefit from an extended lymphadenectomy, including the pelvic lymph nodes. We hypothesised that there are pelvic lymph nodes that receive lymph directly from the primary tumour, thus being at an increased risk for metastasis. In order to determine the frequency of radioactively labelled pelvic lymph nodes and the kinetics of their appearance, we introduce here a combination of dynamic lymphoscintigraphy, single photon emission computed tomography (SPECT) and image fusion of SPECT and pelvic Computed Tomography (CT)-scans. By dynamic lymphoscintigraphy and intraoperative gamma probe detection, superficially located inguinal SLNs (median 2 nodes) could be identified in all of the 51 patients included in this analysis. The histological search for micrometastases was positive in 16 patients (median Breslow thickness of the primary melanoma 2.5 mm). In 29 patients, SPECT and the image fusion technique were additionally performed. Radioactively labelled pelvic lymph nodes were detected in 20 individuals, 6 of them presenting aberrant pelvic SLNs that, on dynamic lymphoscintigraphy, had appeared simultaneously with the superficial SLN(s). Of the 6 patients in whom radioactive pelvic lymph nodes were excised together with the superficial SLN(s), only one had positive superficial SLNs. In this patient, the aberrant pelvic SLN proved to be tumour-positive. In 9 patients, there was no radiotracer uptake in the pelvic lymph nodes at all. Image fusion of SPECT and pelvic CT-scans is an excellent tool to localise exactly the pelvic tumour-draining nodes. The significance of radioactively labelled pelvic lymph nodes for the probability of pelvic metastases should be analysed further.


Subject(s)
Lymph Nodes/diagnostic imaging , Melanoma/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Tomography, Emission-Computed, Single-Photon/methods , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Pelvis , Sentinel Lymph Node Biopsy/methods
18.
Melanoma Res ; 12(5): 499-504, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12394192

ABSTRACT

In patients with lymph node metastasis of malignant melanoma, the incidence of additional locoregional cutaneous metastases has not been well documented. More importantly, the prognostic impact of locoregional cutaneous metastases appearing prior to therapeutic lymphadenectomy is unclear. Using Kaplan-Meier estimations and a Cox proportional hazards model, we addressed these questions in 224 patients with palpable lymph node metastases to the axilla or the groin. The 10 year overall probability to develop regional cutaneous metastasis, calculated from primary tumour excision, was 38.7%. Using univariate and multivariate analysis, Breslow thickness was a significant risk factor of in-transit disease in node-positive patients. In 24 patients (10.7%) locoregional cutaneous metastases had appeared before therapeutic lymphadenectomy, but this was not associated with a survival disadvantage. In conclusion, locoregional cutaneous metastases amenable to surgical excision do not significantly influence the survival prognosis after therapeutic lymphadenectomy. In the subpopulation of patients with lymph node metastasis, Breslow thickness predicts the probability of additional locoregional cutaneous metastasis.


Subject(s)
Lymphatic Metastasis , Melanoma/mortality , Melanoma/pathology , Skin Neoplasms/mortality , Skin Neoplasms/pathology , Disease-Free Survival , Female , Humans , Male , Melanoma/diagnosis , Middle Aged , Multivariate Analysis , Neoplasm Metastasis , Prognosis , Proportional Hazards Models , Risk Factors , Skin Neoplasms/diagnosis , Time Factors
20.
Hautarzt ; 53(8): 536-41, 2002 Aug.
Article in German | MEDLINE | ID: mdl-12221468

ABSTRACT

BACKGROUND AND OBJECTIVE: 224 patients with malignant melanoma and palpable axillary or inguinal lymphadenopathy underwent therapeutic lymph node dissection at the Martin-Luther-University in Halle, Germany. between 1983 and 1994. 120 received adjuvant chemotherapy; we evaluated the effects of various regimens in this group. PATIENTS/METHODS: Surgical treatment alone was performed in 104 patients. This group's results were compared to those of 94 patients who additionally received an adjuvant polychemotherapy [dacarbazine (DTIC), vincristine, 5-fluorouracil and hydroxyurea] and 26 patients who received either DTIC monotherapy or DTIC plus interferon-alfa. RESULTS: The median follow-up was 88 months. The 5-year survival rates were 31.0+/-5% after surgery alone, 26.4+/-4% after adjuvant polychemotherapy and 27.0+/-9% after DTIC based chemotherapy. The three survival curves did not differ significantly. In a multifactorial analysis, the number of metastatic lymph nodes was the single significant predictor of survival after therapeutic lymph node dissection, whereas Breslow thickness, ulceration, site of the primary melanoma, age, sex and adjuvant therapy were not significant. CONCLUSION: No beneficial effect of adjuvant chemotherapies could be demonstrated.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Dacarbazine/administration & dosage , Interferon-alpha/administration & dosage , Lymph Node Excision , Melanoma/drug therapy , Skin Neoplasms/drug therapy , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Chemotherapy, Adjuvant , Combined Modality Therapy , Dacarbazine/adverse effects , Female , Follow-Up Studies , Humans , Interferon-alpha/adverse effects , Lymphatic Metastasis , Male , Melanoma/mortality , Melanoma/pathology , Melanoma/surgery , Middle Aged , Neoplasm Staging , Skin Neoplasms/mortality , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Survival Rate
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