ABSTRACT
Objective: Cognitive impairment (CI) is one of the most common manifestations of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Despite its frequency, we have a limited understanding of the underlying immune mechanisms, resulting in a lack of pathways to target. This study aims to bridge this gap by investigating differences in serum analyte levels in SLE patients based on their cognitive performance, independently from the attribution to SLE, and exploring the potential for various serum analytes to differentiate between SLE patients with and without CI. Methods: Two hundred ninety individuals aged 18-65 years who met the 2019-EULAR/ACR classification criteria for SLE were included. Cognitive function was measured utilizing the adapted ACR-Neuropsychological Battery (ACR-NB). CI was defined as a z-score of ≤-1.5 in two or more domains. The serum levels of nine analytes were measured using ELISA. The data were randomly partitioned into a training (70%) and a test (30%) sets. Differences in the analyte levels between patients with and without CI were determined; and their ability to discriminate CI from non-CI was evaluated. Results: Of 290 patients, 40% (n=116) had CI. Serum levels of S100A8/A9 and MMP-9, were significantly higher in patients with CI (p=0.006 and p=0.036, respectively). For most domains of the ACR-NB, patients with CI had higher S100A8/A9 serum levels than those without. Similarly, S100A8/A9 had a negative relationship with multiple CI tests and the highest AUC (0.74, 95%CI: 0.66-0.88) to differentiate between patients with and without CI. Conclusion: In this large cohort of well-characterized SLE patients, serum S100A8/A9 and MMP-9 were elevated in patients with CI. S100A8/A9 had the greatest discriminatory ability in differentiating between patients with and without CI.
Subject(s)
Cognitive Dysfunction , Lupus Erythematosus, Systemic , Humans , Calgranulin A , Calgranulin B , Cognitive Dysfunction/diagnosis , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Matrix Metalloproteinase 9/metabolismABSTRACT
A adaptabilidade de carreira é um tema amplamente estudado na área de carreira por sua relevância prática e teórica. O objetivo deste estudo foi testar uma versão em português brasileiro da Career Adapt-Abilities Scale (CAAS) com uma amostra de adolescentes, incluindo uma dimensão adicional chamada cooperação. Participaram 592 adolescentes (303 do sexo feminino) de escolas privadas (n=275) e públicas (n=317), em Porto Alegre, RS. Os adolescentes tinham entre 13 e 18 anos (M=15,91 e DP=1,08). Em uma primeira subamostra aleatória (n=296), uma análise fatorial exploratória foi conduzida e resultou em uma solução de cinco fatores. Logo após, com o restante da amostra, foi realizada uma análise fatorial confirmatória, confirmando-se o modelo de cinco dimensões. Os resultados indicam que o instrumento testado possui uma estrutura dimensional compatível com o modelo teórico adotado e propriedades psicométricas aceitáveis, além de contar com o acréscimo da dimensão cooperação.
Career adaptability is a theme widely studied in the area of career for its practical and theoretical relevance. The aim of this study was to test a Brazilian Portuguese version of the Career Adapt-Abilities Scale (CAAS) with a sample of adolescents, and including an additional dimension called cooperation. A total of 592 adolescents participated (303 female) from private (n=275) and public schools (n=317), in Porto Alegre. The adolescents were between 13 and 18 years old (M=16,02 e SD=1,08). In the first random subsample (n=296), an exploratory factor analysis was conducted and resulted in a five-factor solution. Afterwards, with the remainder of the sample, a confirmatory factor analysis was performed, ratifying the five-dimension model. The results indicate that the instrument tested has a dimensional structure compatible with the theoretical model adopted and acceptable psychometric properties, in addition to having the cooperation dimension added.
La adaptabilidad es uno de los temas ampliamente estudiados en el área de carrera, debido a su gran importancia práctica y teórica. El objetivo de este estudio es la creación de una versión brasilera de la escala CAAS, incluyendo la dimensión cooperación y destinada al público adolescente. Participaron 592 adolescentes (303 del sexo femenino) de escuelas privadas (n=275) y públicas (n=317), en Porto Alegre. Los adolescentes tenían entre 13 y 18 años (M=15,91 y DP=1,08). En una primera submuestra aleatoria (n=296), se llevó a cabo un análisis factorial exploratorio que sugirió una solución de cinco factores. Luego, con el resto de la muestra, se realizó un análisis factorial confirmatorio, en el cual se confirmó el modelo de dimensiones. Por lo tanto, se puede llegar a una versión del CAAS con propiedades psicométricas compatibles con estudios anteriores para una muestra de adolescentes brasileños, con la adición de la dimensión cooperación.
