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Amplification of epidermal growth factor receptor gene in renal cell carcinoma.
El-Hariry, Iman; Powles, Thomas; Lau, Mike R; Sternberg, Cora N; Ravaud, Alain; von der Maase, Hans; Zantl, Niko; Harper, Peter; Rolland, Frédéric; Audhuy, Bruno; Barthel, Friederike; Machiels, Jean-Pascal; Patel, Pina; Kreuser, Ernst-Dietrick; Hawkins, Robert E.
Eur J Cancer ; 46(5): 859-62, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20167476

ABSTRACT

Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.


Subject(s)
Carcinoma, Renal Cell/genetics , ErbB Receptors/biosynthesis , Gene Amplification , Gene Expression Regulation, Neoplastic , Kidney Neoplasms/genetics , Adult , Aged , Aged, 80 and over , Carcinoma, Renal Cell/metabolism , ErbB Receptors/genetics , Female , Humans , In Situ Hybridization, Fluorescence , Kidney Neoplasms/metabolism , Male , Middle Aged , Prognosis , Prospective Studies , Survival Analysis
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