[Comparison of fine needle aspiration cytology and histology in hepatocellular carcinoma and in liver metastasis]. / Vergleich von Feinnadelaspirationszytologie und Histologie beim hepatozellulären Karzinom und bei Lebermetastasen.

The cytological findings in fine needle aspiration biopsies of 5 hepatocellular carcinomas and 9 secondary liver tumours were compared with the histological findings in autopsy or surgical material. Definite diagnosis of malignancy was made in all cases. Similarity with liver cells, arrangement of the tumor cells corresponding to the different histological types of hepatocellular carcinoma, and the presence of bile pigment characterize the cytological picture of the hepatocellular carcinoma. Pleomorphic tumour cells and prominent nucleoli are other typical cytological findings. Liver metastasis were correctly typed in nearly all cases by the cytological examinations. The attempt to suggest the primary site is more difficult, but possible in some cases.

[Characterization of experimentally induced malignant gastrointestinal tumors of rats using DNA-cytophotometry and karyometry]. / Charakterisierung experimentell induzierter maligner Gastrointestinaltumoren der Ratte durch DNS-Zytophotometrie und Karyometrie.

The average relative DNA-content, the status of ploidy, the area of the nucleus, the compactness of chromatin and the variability of the shape of the nucleus were determined in 33 experimental induced malignant neoplasms and 5 benign lesions of gastric and intestinal mucosa of rats. The results were compared with diploid controls and divided into 3 types of DNA-histograms. Normal and malignant cells differed significantly in their DNA-content, in the area of the nucleus and in the percentage of hypertetraploid cells. 27 tumors belonged to the aneuploid type of histogram. The dignity was not clear in 6 cases. Diploid carcinomas did not occur. The DNA-cytophotometry gave the decisive hint to diagnosis of malignancy in 8 carcinomas. The various types of tumors differed not in the determined parameters. The problem of differential diagnosis between benign lesions with preneoplastic potential and malignant tumors is discussed.

[Comparative cytophotometric and cytomorphometric studies of concave cells and atypical squamous epithelial cells of the cervix uteri]. / Vergleichende zytophotometrische und zytomorphometrische Untersuchungen an Koilozyten und atypischen Plattenepithelzellen der Cervix uteri.

Cytologic slides from 11 women with clinical, cytological and histological signs of a papillomavirus infection of the cervix uteri are investigated by cytophotometry and cytomorphometry. The mean values of DNA content, chromatin density, nuclear area and nuclear circumference of koilocytes were notably higher than for atypical or normal squamous cells. In those patients with concurrent cervical intraepithelial neoplasia the DNA content of koilocytes was inversely related to the degree of atypia. Squamous cells with HPV-induced lesions can be characterized by cytophotometry and cytomorphometry as a distinct cell population forming a continuum with the preneoplastic epithelium.