[The influence of the low-frequency laser radiation on microcirculatory disorders in the patients presenting with chronic viral hepatitis].

AIM: The objective of the present study was to elucidate the character of microcirculatory disorders in the patients presenting with chronic viral hepatitis and to evaluate the possibilities for the correction of the associated disorders with the use of laser irradiation. Material and methods. All the patients were divided into three groups. Group 1 was comprised of 30 patients who were treated by means of traditional medicamental therapy alone; they served as controls. Group 2 consisted of 45 patients treated by intravenous laser irradiation in addition to traditional medicamental therapy. The patients of group 3 (n=45) received a course of laser skin treatment. The state of microcirculation was assessed by the laser Doppler flowmetry (LDF) technique with the help of a LAKK-02 apparatus (<> Research and Manufacturing Complex, Moscow, Russia). RESULTS: The study has demonstrated heterogeneity of the types of microcirculation with the statistically significant increase in the frequency of its pathological cases. All the patients treated with the use of low-intensity laser therapy exhibited a significant improvement of the blood flow characteristics regardless of the initial hemodynamic type of microcirculation. CONCLUSION: It is concluded that the application of laser irradiation as a component of the combined treatment of the patients presenting with chronic viral hepatitis facilitates correction of microcirculatory disorders.

[[ENDOTHELIAL DYSFUNCTION AND ITS LOW-LEVEL LASER THERAPY CORRECTION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS].

UNLABELLED: The aim of the work to study the influence of the low-intensive laser therapy on the endothelium function in chronic virus hepatitis patients. RESEARCH METHODS: All patients have been divided into three groups: In the first (control) group (30 persons) the traditiona medicamentous therapy was used only, the patients of the experimental 11 group (45 person) alongside with complex medicamentous therapy received the course of intravenous laser therapy and Ill group of patients (45 person) received a rate complex medicamental and laser (cutaneous) therapy. RESULTS: Medicamentous therapy of patients chronic virus hepatites is not accompanied by authentic improvement of the maintenance in plasma of blood NOx, and inclusion in a complex of medical actions of laser therapy promotes authentic improvement of parameters in plasma of blood NOx. THE CONCLUSION: Various methods of laser therapy improve NO--producing function endothelium, improve a functionacondition of vascular endothelium.

[The influence of low-intensity laser radiation on the vascular endothelium function and the cytokine system in patients with chronic viral hepatitis].

The objective of the present work was to study the influence of low-intensity laser therapy on the cytokine system and the function of vascular endothelium in patients presenting with chronic viral hepatitis. The measurement of blood cytokine levels by an immunoenzyme assay revealed a decrease in the levels of anti-inflammatory IL-1-beta, IL-6, and TNF-alpha and a rise in proinflammatory IL-4 in the treated patients compared with the untreated ones. Medicamental therapy of chronic viral hepatitis did not cause a significant reduction in the plasma nitric oxide level whereas inclusion of low-intense laser irradiation in the combined treatment resulted in its normalization. It is concluded that the use of low-intense laser irradiation as a component of combined therapy of patients presenting with chronic viral hepatitis has marked beneficial effect on the cytokine system. Moreover, various methods of such laser therapy improve the functional activity of vascular endothelium and its NO-producing capacity.

[Effect of low-intensity laser radiation on the function of vascular endothelium in patients with chronic viral hepatitis].

The aim of the study was to measure plasma levels of stable metabolites of nitric oxide, nitrates, and nitrites (NOx) in patients with chronic viral hepatitis and evaluate the possibility of their correction by low-power laser irradiation. NO metabolites (total nitrites and nitrates) were measured colorimetrically from the development of colour in the reaction of nitrite with sulfanilamide diazotization in Griess reagent. Colour intensity was determined with Victor2 enzyme immunoanalyzer, Perkin Elmaer (Finland). The patients were divided into three groups. In group 1 (control, n = 30) they received combined medicamentous therapy, in group 2 (n = 45) medicamentous therapy and a course of intravenous laser therapy, in goup 3 (n = 45) medicamentous therapy and skin laserotherapy. The results indicate that medicamentous treatment of patients with chronic hepatitis does not bring any beneficial changes in plasma NOx whose levels are significantly improved in case of simultaneous laser therapy. It is concluded that different laserotherapeutic modalities have beneficial effect on NO-producing function of endothelium and thereby improve its functional state. Compensation of NO deficit by laser therapy ensures overall protection of the organism against free radicals and decreases severity of oxidative stress.