1.
Vestn Ross Akad Med Nauk
; (4): 50-5, 1998.
Article
in Russian
| MEDLINE
| ID: mdl-9633243
ABSTRACT
The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
Subject(s)
Anti-Infective Agents, Local/administration & dosage , Brachyura/enzymology , Collagenases/administration & dosage , Wound Healing/drug effects , Animals , Anti-Infective Agents, Local/adverse effects , Anti-Infective Agents, Local/isolation & purification , Collagenases/adverse effects , Collagenases/isolation & purification , Disease Models, Animal , Male , Ointments , Rats , Rats, Inbred Lew , Safety , Treatment Outcome , Wound Infection/drug therapy , Wound Infection/pathology
2.
Biull Eksp Biol Med
; 124(10): 421-4, 1997 Oct.
Article
in Russian
| MEDLINE
| ID: mdl-9410174