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1.
J Neural Eng ; 18(4)2021 08 12.
Article in English | MEDLINE | ID: mdl-34400592

ABSTRACT

Objective.We derive and demonstrate how residual voltage (RV) from a biphasic electrical stimulation pulse can be used to recognize degradation at the electrode-tissue interface.Approach.Using a first order model of the electrode-tissue interface and a rectangular biphasic stimulation current waveform, we derive the equations for RV as well as RV growth over several stimulation pulses. To demonstrate the use of RV for damage detection, we simulate accelerated damage on sputtered iridium oxide film (SIROF) electrodes using potential cycling. RV measurements of the degraded electrodes are compared against standard characterization methods of cyclic voltammetry and electrochemical impedance spectroscopy.Main results.Our theoretical discussion illustrates how an intrinsic RV arises even from perfectly balanced biphasic pulses due to leakage via the charge-transfer resistance. Preliminary data inin-vivorat experiments follow the derived model of RV growth, thereby validating our hypothesis that RV is a characteristic of the electrode-tissue interface. RV can therefore be utilized for detecting damage at the electrode. Our experimental results for damage detection show that delamination of SIROF electrodes causes a reduction in charge storage capacity, which in turn reflects a measurable increase in RV.Significance.Chronically implanted electrical stimulation systems with multi-electrode arrays have been the focus of physiological engineering research for the last decade. Changes in RV over time can be a quick and effective method to identify and disconnect faulty electrodes in large arrays. Timely diagnoses of electrode status can ensure optimal long term operation, and prevent further damage to the tissue near these electrodes.


Subject(s)
Electrodes, Implanted , Electric Impedance , Electric Stimulation , Electrodes
2.
J Neural Eng ; 18(4)2021 05 04.
Article in English | MEDLINE | ID: mdl-33657542

ABSTRACT

Objective.When currents are injected into the scalp, e.g. during transcranial current stimulation, the resulting currents generated in the brain are substantially affected by the changes in conductivity and geometry of intermediate tissue. In this work, we introduce the concept of 'skull-transparent' currents, for which the changing conductivity does not significantly alter the field while propagating through the head.Approach.We establish transfer functions relating scalp currents to head potentials in accepted simplified models of the head, and find approximations for which skull-transparency holds. The current fields resulting from specified current patterns are calculated in multiple head models, including MRI heads and compared with homogeneous heads to characterize the transparency. Experimental validation is performed by measuring the current field in head phantoms.Main results.The main theoretical result is derived from observing that at high spatial frequencies, in the transfer function relating currents injected into the scalp to potential generated inside the head, the conductivity terms form a multiplicative factor and do not otherwise influence the transfer function. This observation is utilized to design injected current waveforms that maintain nearly identical focusing patterns independently of the changes in skull conductivity and thickness for a wide range of conductivity and thickness values in an idealized spherical head model as well as in a realistic MRI-based head model. Experimental measurements of the current field in an agar-based head phantom confirm the transparency of these patterns.Significance.Our results suggest the possibility that well-chosen patterns of current injection result in precise focusing inside the brain even withouta prioriknowledge of exact conductivities of intermediate layers.


Subject(s)
Electroencephalography , Skull , Brain/diagnostic imaging , Computer Simulation , Electric Conductivity , Head/diagnostic imaging , Magnetic Resonance Imaging , Skull/diagnostic imaging
3.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3973-3976, 2020 07.
Article in English | MEDLINE | ID: mdl-33018870

ABSTRACT

Low electrode-skin impedance can be achieved if the interface has an electrolytic medium that allows the movement of ions across the interface. Maintaining good physical contact of the sensor with the skin is imperative. We propose a novel hydrophilic conductive sponge interface that encapsulates both of these fundamental concepts into an effective physical realization. Our implementation uses a hydrophilic polyurethane prepolymer doped with conductive carbon nanofibers and cured to form a flexible sponge material that conforms to uneven surfaces, for instance, on parts of the scalp with hair. Our results show that our sponges are able to stay in a hydrated state with a low electrode-skin impedance of around 5kΩ for more than 20 hours. The novelty in our conductive sponges also lies in their versatility: the carbon nanofibers make the electrode effective even when the electrode dries up. The sensors remain conductive with a skin impedance on the order of 20kΩ when dry, which is substantially lower than typical impedance of dry electrodes, and are able to extract alpha wave EEG activity in both wet and dry conditions.


Subject(s)
Electroencephalography , Electric Conductivity , Electric Impedance , Electrodes , Equipment Design
4.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 6151-6154, 2020 07.
Article in English | MEDLINE | ID: mdl-33019375

ABSTRACT

EEG is a powerful and affordable brain sensing and imaging tool used extensively for the diagnosis of neurological disorders (e.g. epilepsy), brain computer interfacing, and basic neuroscience. Unfortunately, most EEG electrodes and systems are not designed to accommodate coarse and curly hair common in individuals of African descent. In neuroscience studies, this can lead to poor quality data that might be discarded in scientific studies after recording from a broader population set. In clinical diagnoses, it may lead to an uncomfortable and/or emotionally taxing experience, and, in the worst cases, misdiagnosis. Our prior work demonstrated that braiding hair in cornrows to expose the scalp at target locations leads to reduced electrode-skin impedance for existing electrodes. In this work, we design and implement novel electrodes that harness braided hair, and demonstrate that, across time, our electrodes, in conjunction with braiding, lower the impedance further, attaining 10x lower impedance than existing systems.


Subject(s)
Electroencephalography , Scalp , Electric Impedance , Electrodes , Equipment Design , Humans
5.
Annu Int Conf IEEE Eng Med Biol Soc ; 2018: 1287-1290, 2018 Jul.
Article in English | MEDLINE | ID: mdl-30440626

ABSTRACT

We propose a novel carbon fiber-based conductive silicone sponge for low electrode-skin impedance EEG recordings. When this sponge is used with water or saline solution, no gel is required, lowering the setup time drastically compared to classical wet electrodes. Moreover, the wet conductive carbon fiber silicone sponges achieve an electrode-skin impedance as low as $2.5\mathrm {k} \Omega $ at 1kHz when wet, making them better than state of the art gel electrodes. Additionally, even as the sponge dries out, it continues to remain conductive and performs as a reliable dry electrode. We demonstrate through experiments that these conductive carbon fiber silicone sponge electrodes, wet or dry, are able to measure alpha wave activity. Our carbon fiber conductive sponge electrodes are low-cost and are highly suitable for designs of portable high density EEG measurement systems.


Subject(s)
Carbon Fiber , Electroencephalography , Electric Conductivity , Electrodes , Silicones
6.
Article in English | MEDLINE | ID: mdl-27231725

ABSTRACT

Current technology has enabled a significant increase in the number of electrodes for electrical stimulation. For large arrays of electrodes, it becomes increasingly difficult to monitor and detect failures at the stimulation site. In this paper, we propose the idea that the residual voltage from a biphasic electrical stimulation pulse can serve to recognize damage at the electrode-tissue interface. We use a simple switch circuit approach to estimate the relaxation time constant of the electrode model, which essentially models the residual voltage in biphasic electrical stimulation, and compare it with standard electrode characterization techniques. Out of 15 electrodes in a polyimide-based SIROF array, our approach highlights 3 damaged electrodes, consistent with measurements made using cyclic voltammetry and electrode impedance spectroscopy.

7.
IEEE Biomed Circuits Syst Conf ; 2014: 216-219, 2014 Oct.
Article in English | MEDLINE | ID: mdl-27231724

ABSTRACT

Safety features embedded in a 256-channel retinal prosthesis integrated circuit are presented. The biology of the retina and the electrochemistry of the electrode-tissue interface demand careful planning and design of the safety features of an implantable retinal stimulation device. We describe the internal limits and communication safety features of our ASIC, but we focus on monitoring and protection circuits for the electrode-tissue interface. Two independent voltage monitoring circuits for each channel measure the electrode polarization voltage at two different times in the biphasic stimulation cycle. The monitors ensure that the charged electrode stays within the electrochemical water window potentials, and that the discharged electrode is within a small window near the counter electrode potential. A switch to connect each electrode to the counter electrode between pulses protects against a wide range of device failures. Additionally, we describe work on an active feedback system to ensure that the electrode voltage is at zero.

8.
Article in English | MEDLINE | ID: mdl-23366780

ABSTRACT

Functional electrical stimulation of neural tissue is traditionally performed with symmetric cathodic-first biphasic pulses of current through an electrode/electrolyte interface. When the interface is modeled by a series R-C circuit, as is sometimes done for stimulator circuit design, the appearance of a net residual voltage across the electrode cannot be explained. Residual voltage can cause polarization of the electrode and pose a problem for safe electrical stimulation. This paper aims to (1) theoretically explain one reason for the residual voltage, which is the inclusion of the Faradaic impedance (2) suggest a simple dynamic feedback mechanism to eliminate residual voltage.


Subject(s)
Electricity , Nervous System Physiological Phenomena , Electric Stimulation , Electrodes , Feedback , Humans , Signal Processing, Computer-Assisted
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