ABSTRACT
Malignant melanoma involving the gastrointestinal (GI) tract is diagnosed premortem in only 4 per cent of patients with the disease, even though in autopsy series 60 per cent of patients who died of malignant melanoma have GI metastases. Usually, these GI lesions are metastatic. However, a few cases of primary GI malignant melanoma have been reported. Such a case is reported and discussed, including the clinical presentation, pathophysiology, treatment, and prognosis of this disease.
Subject(s)
Jejunal Neoplasms/epidemiology , Melanoma/epidemiology , Colonic Neoplasms/secondary , Female , Humans , Jejunal Neoplasms/pathology , Jejunal Neoplasms/surgery , Jejunum/pathology , Melanoma/secondary , Melanoma/surgery , Middle Aged , PrognosisABSTRACT
A case of ovarian carcinoma with bilateral metastases to the breasts is presented. This is the first report of simultaneous involvement of both breasts presenting as an inflammatory tumor. Axillary lymph node enlargement preceded breast involvement. The related literature is reviewed briefly, and the unpredictable invasiveness of malignant neoplasms is emphasized.
Subject(s)
Adenocarcinoma, Papillary/secondary , Breast Neoplasms/secondary , Ovarian Neoplasms , Adenocarcinoma, Papillary/diagnosis , Adenocarcinoma, Papillary/therapy , Breast Diseases/chemically induced , Breast Neoplasms/diagnosis , Breast Neoplasms/therapy , Diagnosis, Differential , Female , Humans , Middle Aged , Necrosis , Ovarian Neoplasms/therapy , Warfarin/adverse effectsABSTRACT
Acute promyelocytic leukemia developed in a patient with congenital hypoplastic anemia (CHA). The patient had Turner's phenotype, but no chromosomal abnormality. The literature on CHA is briefly reviewed, and the relationship between leukemia and cytotoxic therapy is considered.
