1.
Sci Rep
; 7(1): 15750, 2017 11 16.
Article
in English
| MEDLINE
| ID: mdl-29146972
ABSTRACT
A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM).
Subject(s)
Melanoma/pathology , Peptides/pharmacology , Photochemotherapy , Photosensitizing Agents/pharmacology , Animals , Cell Proliferation , Chlorophyll/analogs & derivatives , Chlorophyll/chemistry , Humans , Ligands , Methylene Blue/chemistry , Mice , Receptors, Melanocortin/metabolism
2.
Exp Dermatol
; 26(3): 281-284, 2017 03.
Article
in English
| MEDLINE
| ID: mdl-27572471