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Isolation of hen's egg phosphonolipids by thin-layer chromatography, their identification and silicic acid column chromatographic separation.

Moschidis, M C; Demopoulos, C A; Kritikou, L G.

J Chromatogr ; 292(2): 473-8, 1984 Jun 01.

Article in English | MEDLINE | ID: mdl-6746799

Subject(s)

Eggs/analysis , Phospholipids/isolation & purification , Animals , Chickens , Chromatography, Ion Exchange/methods , Chromatography, Thin Layer/methods , Female , Magnetic Resonance Spectroscopy/methods , Phospholipids/analysis , Spectrophotometry, Infrared/methods

Phosphono-platelet activating factor I. Synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency.

Moschidis, M C; Demopoulos, C A; Kritikou, L G.

Chem Phys Lipids ; 33(1): 87-92, 1983 Jul.

Article in English | MEDLINE | ID: mdl-6627527

ABSTRACT

The total synthesis of 1-O-alkyl-2-acetyl-3-glyceryl-(2-trimethyl ammoniummethyl) phosphonate, the phosphono analogue of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, is described. The phosphonolipid shows much lower activity than the phospholipid stimulating serotonin release from rabbit platelets.

Subject(s)

Blood Platelets/drug effects , Platelet Activating Factor/analogs & derivatives , Animals , Phospholipids/chemical synthesis , Phospholipids/pharmacology , Platelet Activating Factor/chemical synthesis , Platelet Activating Factor/pharmacology , Rabbits , Serotonin/metabolism , Structure-Activity Relationship

Subject(s)

ABSTRACT

Subject(s)

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