ABSTRACT
The morphology of neoangiogenesis in breast carcinoma tissue is considered as a relationship between the density of the tumor vascular bed and different indices (age, histological type of a tumor, stage of the disease, tumor anaplastic proliferative activity, fibrosis degree, stromal cellularity, and parenchymal destructive changes).
Subject(s)
Breast Neoplasms/blood supply , Neovascularization, Pathologic , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Female , HumansABSTRACT
Extent of viable tumor parenchyma and necrotic tissue as well as grade of tumor cell apoptosis were assessed using histological samples from 377 patients with invasive ductal carcinoma of the breast. No preoperative chemo- or radiotherapy was given. Patients of varying age were examined for destructive changes in tumor nodes both in absence and presence of regional metastases. The highest viability was registered in patients aged 30-39 years. There was a reverse correlation between age, on the one hand, and extent of intact tumor parenchyma, on the other. Similarly, the same age group revealed relatively pronounced destructive changes such as necrosis and apoptosis which are generally characteristic of younger age. There was a significant relationship between extent of destructive changes and malignant anaplasia.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Adult , Age Factors , Aged , Apoptosis , Carcinoma, Ductal, Breast/secondary , Female , Humans , Middle Aged , NecrosisSubject(s)
Biomarkers, Tumor/metabolism , Breast Neoplasms/pathology , Adult , Breast Neoplasms/metabolism , Female , Humans , Lymphatic Metastasis , Matrix Metalloproteinases/metabolism , Necrosis , Predictive Value of Tests , Prognosis , Receptor, ErbB-2/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Tenascin/metabolismABSTRACT
377 patients aged 30 to 79 years who had breast carcinoma were examined to study the age-related features of tumor anaplasia. The degree of tumor anaplasia was studied, in primary nodules, less and more than 2.5 cm in diameter in patients of different ages. This index decreased with age. This may explain more a malignant course of the disease in young patients.
