Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Hypertension/drug therapy , Lisinopril/therapeutic use , Adult , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Blood Chemical Analysis , Blood Pressure/drug effects , Humans , Lisinopril/pharmacology , Male , Middle AgedABSTRACT
A 7-year prospective study of 379 hypertensive patients was conducted with primary comprehensive clinical and device examination of the patients in hospital followed by annual control in hospital or outpatient setting. Two groups were formed: with uncomplicated essential hypertension (EH)(n = 263, group 1); with EH complicated by brain infarction (BI) (n = 116, group 2). Overall prognostic correctness was 85.9%. BI was predicted by age, smoking, high intake of salt, absence of regular antihypertensive therapy, non-dipper pattern, low output, atherosclerotic changes of major head arteries, frequent paroxysms of cardiac fibrillation, ventricular extrasystole, abnormal blood rheology. Integral index of the patient condition calculated on the basis of the decisive prognosis rule (data of the primary examination + MI within 7-year follow-up) enables targeted prevention of cerebral complications.
Subject(s)
Cerebral Infarction/etiology , Hypertension/complications , Adult , Cerebral Infarction/physiopathology , Female , Humans , Hypertension/diagnostic imaging , Hypertension/physiopathology , Male , Middle Aged , Predictive Value of Tests , Prognosis , Risk Factors , Ultrasonography, DopplerSubject(s)
Lipids/blood , Myocardial Ischemia/blood , Myocardial Ischemia/therapy , Aged , Combined Modality Therapy , Diet, Fat-Restricted , Humans , Hypercholesterolemia/blood , Hypercholesterolemia/therapy , Hypolipidemic Agents/therapeutic use , Lipoproteins/isolation & purification , Male , Middle AgedSubject(s)
Coronary Disease/complications , Hypertension, Pulmonary/complications , Aged , Female , HumansABSTRACT
Bronchial asthma runs its course in association with marked blood viscosity which lies in a decrease of deformability of red blood cells and suspension stability of red blood cells, an increase of their aggregation capacity and of whole blood viscosity, of platelet proneness to decelerated and little noticeable aggregation, in hyperfibrinogenemia and hyperglobulinemia. Therapeutic plasmapheresis produces a favourable action on changes of the rheological blood properties in bronchial asthma patients. Plasmapheresis entails an improvement of whole blood viscosity and red blood cell aggregation, accompanied, however, by aggravation of the aggregation properties of platelets. Therapeutic plasmapheresis can be used for correction of the syndrome of high blood viscosity in bronchial asthma patients.
