ABSTRACT
INTRODUCTION: One of the common side effects of antipsychotic drugs is excessive sedation. The treatment with antipsychotics often manifests as an increase in slow wave activity in electroencephalography (EEG). The aim of this study was to analyze EEG recordings of patients treated with a non-sedative antipsychotic drug sertindole with regard to its adverse effects and clinical efficacy. PATIENTS AND METHODS: EEG recordings of 45 patients (27 females, mean age 30.1±8.7 years) with schizophrenia were analyzed. EEG recordings were categorized based on abnormalities severity. The clinical efficacy was rated on the Clinical Global Impression Scale. RESULTS: Abnormalities from mild to moderate were found in 29% of the group. Clinical improvement was observed in 80% of patients. Sedation/daytime sleepiness was present in 7% of patients. Other side effects were prolongation of QTc (11%, severe 4%), insomnia (9%), extrapyramidal symptoms (7%), and heart palpitations (2%). CONCLUSIONS: Patients treated with sertindole do not show side effects similar to those found during treatment with other antipsychotic drugs. Increased slow wave activity in EEG and sedation were absent in the majority of the investigated patients.
Subject(s)
Antipsychotic Agents/therapeutic use , Brain Waves/drug effects , Imidazoles/therapeutic use , Indoles/therapeutic use , Schizophrenia, Paranoid/drug therapy , Schizophrenia, Paranoid/physiopathology , Adult , Electroencephalography , Female , Humans , Male , Treatment Outcome , Young AdultABSTRACT
The aim of the paper was to estimate in vitro the effect of electromagnetic field produced by mobile phones on the activity of superoxide dismutase (SOD-1) in human blood platelets. Suspension of blood platelets exposed to the electromagnetic field of 900 MHz frequency for 1, 3, 5, 7 minutes. Our studies demonstrated that microwaves produced by mobiles significally depleted the activity of SOD-1 after 1, 5, 7 min. of exposition and increased after 3 min. nn comparison wit control test. On the ground of our results we conclude that oxidative stress after exposition to microwaves can be the reason of many disadvantageous changes in cells and may cause many systemic consequences in human organism.
