1.
Biochem Pharmacol
; 33(18): 2926-8, 1984 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-6332628
Subject(s)
Calcium/physiology , Nifedipine/analogs & derivatives , Skin/drug effects , Water-Electrolyte Balance/drug effects , Amiloride/pharmacology , Animals , Calcium Channel Blockers/pharmacology , Electric Conductivity , In Vitro Techniques , Nifedipine/pharmacology , Nisoldipine , Rana esculenta , Sodium/metabolism
2.
Invest Ophthalmol Vis Sci
; 22(5): 686-90, 1982 May.
Article
in English
| MEDLINE
| ID: mdl-7076412
ABSTRACT
Cyclosporin A (CS-A), selectively inhibited cellular immunity, delayed the skin graft-induced rejection of corneal allografts in rabbits when administered subconjunctivally in the dose of 3 mg/kg/day or in the form of 5% water-soluble drops five times daily for 28 days. The subconjunctival application of CS-A was irritating, whereas the topical instillation of the water-soluble preparation was well tolerated. The corneal grafts were rejected after discontinuation of the therapy. Rejection was confirmed by scanning and transmission electron microscopy. The mechanism by which CS-A delayed corneal graft rejection seems to depend mainly on the specific and/or the nonspecific effect of topical CS-A on lymphocytes.
Subject(s)
Cyclosporins/pharmacology , Graft Survival/drug effects , Retina/transplantation , Administration, Topical , Animals , Cyclosporins/administration & dosage , Graft Rejection/drug effects , Models, Biological , Ophthalmic Solutions , Rabbits , Retina/pathology , Transplantation, Homologous
3.
Fortschr Ophthalmol
; 79(2): 132-4, 1982.
Article
in German
| MEDLINE
| ID: mdl-6764207