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Radiats Biol Radioecol ; 36(2): 190-4, 1996.
Article in Russian | MEDLINE | ID: mdl-8673217

ABSTRACT

The cysteamine derivative-guanidinoethanesulfanylthiosulfuric acid was demonstrated to have radioprotective properties protecting mice against X-rays and fission neutron irradiation hazard. Radioprotective efficacy shows itself for 2 hours after i.p. and p.o. administration of the preparation. It was established an opportunity of the prolonged protective action of gammaphos as a result of its cross-linking to dextran. The preparation has a radioprotective action on X-ray and neutron irradiation.


Subject(s)
Amifostine/pharmacology , Dextrans/pharmacology , Organothiophosphorus Compounds/pharmacology , Radiation-Protective Agents/pharmacology , Amifostine/administration & dosage , Animals , Delayed-Action Preparations , Dextrans/administration & dosage , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neutrons , Organothiophosphorus Compounds/administration & dosage , Radiation Dosage , Radiation-Protective Agents/administration & dosage , Time Factors
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