IMMUNITY CHANGES IN PATIENTS WITH ACUTE MAXILLOFACIAL ODONTOGENIC INFECTIONS DURING TREATMENT STAGES: AN ANALYSIS.

OBJECTIVE: The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity. PATIENTS AND METHODS: Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients. We assessed changes in total protein and its fractions, C-reactive protein (CRP), lysozyme, and immunoglobulins (A, M, and G) during three distinct time intervals: 1-3 days, 5-7 days, and 8-14 days after treatment initiation. Statistical analysis was conducted using Statistica 10.0 (StatSoft, Inc., USA) and Microsoft Office Excel 2010. RESULTS: Results: At different postoperative follow-up periods, a significant improvement in humoral nonspecific immunity indicators (p>0.05) was observed when comparing patients treated with and without platelet-rich plasma. This improvement is expected to enhance reparative processes and expedite recovery. CONCLUSION: Conclusions: The incorporation of platelet-rich plasma, immunocorrective, and adaptogenic therapy into the comprehensive treatment of acute purulent odontogenic inflammatory processes in the maxillofacial region not only leads to pronounced and enduring positive outcomes but also results in substantial improvements, including the potential normalization of key humoral and cellular factors associated with innate immunity.

THE QUALITY OF DRINKING WATER AS A FACTOR IN THE FORMATION OF DENTAL PATHOLOGY OF THE HARD TISSUES OF THE TEETH IN CHILDREN.

OBJECTIVE: The aim: A study of the impact of drinking water quality on the state of dental health in schoolchildren who permanently live in areas of biogeochemical deficiency of fluorine and iodine. PATIENTS AND METHODS: Material and methods: The composition of the drinking water of the city of Uzhhorod and the city of Rakhiv has been investigated. The prevalence and intensity of dental caries in children is determined, drinking water is taken in accordance with Uzhhorod and Rakhiv. RESULTS: Results: The regional features of the composition of drinking water of the mountain Rakhivsky district of the Transcarpathian region are the high variety of combinations of mineral components and the frequent excess of the normative content of dry residue components, namely nitrates, sulfates, chlorides, magnesium and calcium.Water oxidation, total stiffness and total alkalinity were significantly different. The established drinking water quality indicators have a direct dependence on the prevalence and intensity of dental caries in children, that is, a significant increase in the number of carious temporary, carious and distant permanent teeth and a decrease in filled temporary and permanent teeth (p < 0. 05) were diagnosed. CONCLUSION: Conclusions: One of the most pressing problems in water hygiene is the urgent need to review and improve regulations, State sanitary regulations, standards and other regulations in the field of drinking water, including through the development of regional drinking water quality standards.