Passive artifact behavior prediction of interventional tools in high-field MRI using a 0.55T portable benchtop MR scanner.

Using magnetic resonance imaging (MRI) for guiding minimally invasive interventions requires surgical devices which on one hand are visible in the MR image but on the other hand do not generate large artifacts, which distort the overall imaging process. Passive markers are one way to visualize devices such as catheters or biopsy needles in MRI. The evaluation of newly developed passive markers usually requires access to high-field MRI scanners (1.5 T and 3 T). This makes the practical evaluation time-consuming and expensive. Hence, we propose to use a high-resolution, low field (0.55 T) benchtop MRI system to quantify the size of an artifact and to make a prediction for its corresponding size in a clinical high-field system. For the evaluation of the proposed method, catheters coated with different passive marker materials in varying concentrations were imaged in the 0. 55 T benchtop MRI scanner as well as in clinical 3 T MRI system using FLASH sequences. The experimental results revealed that an artifact prediction based on measurements in the 0. 55 T is possible for the tested marker materials. Hence, the proposed approach has a high potential for testing newly developed medical devices at a low cost, in less time and during the development process for fast feedback.

[Indications for catheter ablation of ventricular tachycardia]. / Indikationen zur Katheterablation bei ventrikulärer Tachykardie.

Ventricular tachyarrhythmias (VT) can cause sudden cardiac death. This can be prevented by an implantable cardioverter-defibrillator (ICD) but approximately 25% of patients with an ICD develop electrical storm (≥ 3 VTs within 24 hours) during the course of 4-5 years. This is a life-threatening event even in the presence of an ICD, particularly if incessant VT is present, and may significantly deteriorate the patient's psychological state if multiple shocks are discharged. Catheter ablation of VT has developed into a standard procedure in many specialized electrophysiology centers. Patients with hemodynamically stable and unstable VT are amendable to substrate-based ablation strategies. Catheter ablation can be performed as emergency procedure in patients with electrical storm as well as electively in patients with monomorphic VT stored in ICD memory. In patients with ischemic or non-ischemic cardiomyopathy, VT ablation is complementary to ICD implantation and can reduce the number of ventricular arrhythmia episodes and shocks and should be performed early. In patients with electrical storm, catheter ablation can acutely achieve rhythm stabilization and may improve prognosis in the long term. Further indications for catheter ablation exist in patients with idiopathic VT where catheter ablation represents a curative therapy, and in patients with symptomatic or asymptomatic frequent premature ventricular beats which may improve prognosis in patients with heart failure and cardiac resynchronization therapy.

Rounding effects in record statistics.

We analyze record-breaking events in time series of continuous random variables that are subsequently discretized by rounding to integer multiples of a discretization scale Δ>0. Rounding leads to ties of an existing record, thereby reducing the number of new records. For an infinite number of random variables that are drawn from distributions with a finite upper limit, the number of discrete records is finite, while for distributions with a thinner than exponential upper tail, fewer discrete records arise compared to continuous variables. In the latter case, the record sequence becomes highly regular at long times.

Correlations of record events as a test for heavy-tailed distributions.

A record is an entry in a time series that is larger or smaller than all previous entries. If the time series consists of independent, identically distributed random variables with a superimposed linear trend, record events are positively (negatively) correlated when the tail of the distribution is heavier (lighter) than exponential. Here we use these correlations to detect heavy-tailed behavior in small sets of independent random variables. The method consists of converting random subsets of the data into time series with a tunable linear drift and computing the resulting record correlations.

Real-time view of mesoscopic surface diffusion.

Photoemission electron microscopy is used to study the thermal decay of Ag islands grown epitaxially on Si(001) surfaces. (2 x 3) Ag reconstructed zones, due to migrating Ag atoms supplied to the surface by the decaying islands, surround each of the islands. The shape of these reconstructed zones depends on the degree of diffusion isotropy in the system. We demonstrate that the imaging of these reconstructed "isocoverage zones" constitutes a unique experimental method for directly observing diffusion fields in epitaxial systems. We describe the dynamics of the thermal decay of the islands and the isozones in the context of a continuum diffusion model.

Rapid roughening in thin film growth of an organic semiconductor (diindenoperylene).

The scaling exponents alpha, beta, and 1/z in thin films of the organic molecule diindenoperylene deposited on SiO2 under UHV conditions are determined. Atomic-force microscopy, x-ray reflectivity, and diffuse x-ray scattering were employed. The surface width displays power law scaling over more than 2 orders of magnitude in film thickness. We obtained alpha = 0.684+/-0.06, beta = 0.748+/-0.05, and 1/zeta = 0.92+/-0.20. The derived exponents point to an unusually rapid growth of vertical roughness and lateral correlations. We suggest that they could be related to lateral inhomogeneities arising from the formation of grain boundaries between tilt domains in the early stages of growth.

Coarsening of sand ripples in mass transfer models.

Coarsening of sand ripples is studied in a one-dimensional stochastic model, where neighboring ripples exchange mass with algebraic rates, Gamma(m) approximately m(gamma), and ripples of zero mass are removed from the system. For gamma<0, ripples vanish through rare fluctuations and the average ripple mass grows as (t) approximately -gamma(-1)ln(t). Temporal correlations decay as t(-1/2) or t(-2/3) depending on the symmetry of the mass transfer, and asymptotically the system is characterized by a product measure. The stationary ripple mass distribution is obtained exactly. For gamma>0, ripple evolution is linearly unstable, and the noise in the dynamics is irrelevant. For gamma=1, the problem is solved on the mean-field level, but the mean-field theory does not adequately describe the full behavior of the coarsening. In particular, it fails to account for the numerically observed universality with respect to the initial ripple size distribution. The results are not restricted to sand ripple evolution since the model can be mapped to zero range processes, urn models, exclusion processes, and cluster-cluster aggregation.

Pattern dynamics of vortex ripples in sand: nonlinear modeling and experimental validation.

Vortex ripples in sand are studied experimentally in a one-dimensional setup with periodic boundary conditions. The nonlinear evolution, far from the onset of instability, is analyzed in the framework of a simple model developed for homogeneous patterns. The interaction function describing the mass transport between neighboring ripples is extracted from experimental runs using a recently proposed method for data analysis, and the predictions of the model are compared to the experiment. An analytic explanation of the wavelength selection mechanism in the model is provided, and the width of the stable band of ripples is measured.

Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA).

UNLABELLED: ABSTRACT AIMS/HYPOTHESIS: This study aimed to define the immunological parameters which could be used to identify patients with the distinct metabolic features of adult latent autoimmune diabetes. METHODS: Sera of 312 patients with short-term diabetes (duration < 5 years) over 35 years of age at diagnosis were screened for ICA, GAD- and IA2-Ab by antibody assays validated in workshops. The antibody status was correlated with age, BMI, residual beta-cell function, measured by fasting C-peptide, onset of diabetes-related complications and markers of the metabolic syndrome (hypertension and hyperlipidaemia). RESULTS: A total of 51 antibody positive patients were identified. These patients had lower fasting C-peptide and less neuropathy and hypertension compared with matched antibody-negative patients. However, only patients with two or more antibodies had reduced residual beta-cell function compared with antibody-negative or single antibody-positive (ICA or GAD-Ab only) patients. Patients with two or more antibodies were also leaner and had diabetes-related complications or hypertension less frequently than single antibody-positive or antibody negative-patients. IA2 antibody status did not substantially contribute to the diagnosis or differentiation of LADA patients. CONCLUSION/INTERPRETATION: We concluded that the combination of ICA and GAD antibodies and high titre of GAD antibodies are characteristic of patients with insulin deficiency with the clinical features of Type I (insulin-dependent) diabetes mellitus (LADA-type 1). Single antibody positivity and low titre antibodies are markers for LADA-type 2 associated with the clinical and metabolic phenotype of Type II (non-insulin-dependent) diabetes patients.

Minimal current phase and universal boundary layers in driven diffusive systems.

We investigate boundary-driven phase transitions in open driven diffusive systems. The generic phase diagram for systems with short-ranged interactions is governed by a simple extremal principle for the macroscopic current, which results from an interplay of density fluctuations with the motion of shocks. In systems with more than one extremum in the current-density relation, one finds a minimal current phase even though the boundaries support a higher current. The boundary layers of the critical minimal current and maximal current phases are argued to be of a universal form. The predictions of the theory are confirmed by Monte Carlo simulations of the two-parameter family of stochastic particle hopping models of Katz, Lebowitz, and Spohn and by analytical results for a related cellular automaton with deterministic bulk dynamics. The effect of disorder in the particle jump rates on the boundary layer profile is also discussed.

Asymptotic step profiles from a nonlinear growth equation for vicinal surfaces

We study a recently proposed nonlinear evolution equation describing the collective step meander on a vicinal surface subject to the Bales-Zangwill growth instability [O. Pierre-Louis et al., Phys. Rev. Lett. 80, 4221 (1998)]. A careful numerical analysis shows that the dynamically selected step profile consists of sloped segments, given by an inverse error function and steepening as sqrt[t], which are matched to pieces of a stationary (time-independent) solution describing the maxima and minima. The effect of smoothening by step-edge diffusion is included heuristically, and a one-parameter family of evolution equations is introduced that contains relaxation by step-edge diffusion and by attachment-detachment as special cases. The question of the persistence of an initially imposed meander wavelength is investigated in relation to recent experiments.

Fluorometric analysis of DNA unwinding (FADU) as a method for detecting repair-induced DNA strand breaks in UV-irradiated mammalian cells.

Fluorometric analysis of DNA unwinding (FADU assay) was originally designed to detect X-ray-induced DNA damage in repair-proficient and repair-deficient mammalian cell lines. The method was modified and applied to detect DNA strand breaks in Chinese hamster ovary (CHO) cells exposed to ionizing radiation as well as to UV light. Exposed cells were allowed to repair damaged DNA by incubation for up to 1 h after exposure under standard growth conditions in the presence and in the absence of the DNA synthesis inhibitor aphidicolin. Thereafter, cell lysates were mixed with 0.15 M sodium hydroxide, and DNA unwinding took place at pH 12.1 for 30 min at 20 degrees C. The amount of DNA remaining double-stranded after alkaline reaction was detected by binding to the Hoechst 33258 dye (bisbenzimide) and measuring the fluorescence. After exposure to X-rays DNA strand breaks were observed in all cell lines immediately after exposure with subsequent restitution of high molecular weight DNA during postexposure incubation. In contrast, after UV exposure delayed production of DNA strand break was observed only in cell lines proficient for nucleotide excision repair of DNA photoproducts. Here strand break production was enhanced when the polymerization step was inhibited by adding the repair inhibitor aphidicolin during repair incubation. These results demonstrate that the FADU approach is suitable to distinguish between different DNA lesions (strand breaks versus base alterations) preferentially induced by different environmental radiations (X-rays versus UV) and to distinguish between the different biochemical processes during damage repair (incision versus polymerization and ligation).

Umbilical artery catheter blood sampling decreases cerebral blood volume and oxygenation in very low birthweight infants.

UNLABELLED: The aim of this study was to assess whether blood sampling from umbilical artery catheters reduces cerebral blood volume and cerebral oxygenation in very low birthweight infants. A total of 20 infants, median birthweight 890 g (530-1,500 g), median gestation age 26 +4 wk (range: 22 +5 to 30 +6 wk) were studied from 10 min before until 10 min after routine blood sampling from umbilical artery catheters placed in the high position. Using near infrared spectroscopy, changes in concentrations of cerebral oxygenated and deoxygenated haemoglobin were measured, and changes in cerebral blood volume and cerebral oxygenation index were calculated. Heart rate, oxygen saturation, transcutaneous PO2 and PCO2 were registered continuously. Mean arterial blood pressure was measured before and after sampling. Oxygenated haemoglobin decreased significantly from baseline during blood sampling, whereas deoxygenated haemoglobin did not change significantly. This resulted in a decrease in cerebral blood volume and cerebral oxygenation index. Heart rate increased slightly, but significantly, from baseline. Oxygen saturation, blood pressure, transcutaneous PO2 and PCO2 did not change significantly. CONCLUSION: Blood sampling from umbilical artery catheters induces a significant decrease in cerebral blood volume and cerebral oxygenation.

Fast coarsening in unstable epitaxy with desorption.

Homoepitaxial growth is unstable towards the formation of pyramidal mounds when interlayer transport is reduced due to activation barriers to hopping at step edges. Simulations of a lattice model and a continuum equation show that a small amount of desorption dramatically speeds up the coarsening of the mound array, leading to coarsening exponents between 1/3 and 1/2. The underlying mechanism is the faster growth of larger mounds due to their lower evaporation rate.

Analytic approach to the critical density in cellular automata for traffic flow.

The jamming transition in the stochastic traffic cellular automaton of Nagel and Schreckenberg [J. Phys. I 2, 2221 (1992)] is examined. We argue that most features of the transition found in the deterministic limit do not persist in the presence of noise, and suggest instead to define the transition to take place at that critical density rho(c) at which a large initial jam just fails to dissolve. We show that rho(c)=v(J)/(v(J)+v(F)), where v(F) is the velocity of noninteracting vehicles and v(J) is the speed of the dissolution wave moving into the jam. An approximate analytic calculation of v(J) in the framework of a simple renormalization scheme is presented, which explicitly displays the effect of the interaction between vehicles during the acceleration stage of the Nagel-Schreckenberg rules with maximum velocity v(max)>1. The analytic prediction is compared to numerical simulations. We find a remarkable correspondence between the analytic expression for v(J) and a phase diagram obtained numerically by Lübeck et al.

[Interferon therapy and autoimmunity]. / Interferontherapie und Autoimmunität.

The treatment of viral hepatitis or malignomas with interferon (IFN) can increase the incidence of autoimmune disease. This paper reviews published case and study reports. The incidence of overt autoimmune diseases under IFN treatment is about 3%. Autoantibodies can be detected in 23% of the patients. Autoimmune thyroid diseases are the most frequent ones, but nearly all autoimmune diseases can occur. Beside benign and reversible courses chronic developments and lethal outcomes are possible. Actual concepts concerning the pathogenesis of IFN-associated autoimmunity include induction of MHC and other molecules as well as the modulation of lymphocyte functions. Clinical and paraclinical controls are necessary under treatment with IFN and during follow-up.