[Mechanisms of anti-inflammatory activity of antioxidants in lung tuberculosis]. / O mekhanizmakh protivovospalitelnogo deistviia antioksidantov pri tuberkulëze lëgkikh.

The experiment on 120 non-inbred albino rats with induced pulmonary destructive tuberculosis has established that the antiinflammatory action of the antioxidant dibunol is displayed through changes in the ratio of biologically active 11-hydroxycorticosteroids--free hydrocortisone and corticosterone.

[Lymphocyte enzymes, activity of lipid peroxidation processes and the antioxidant protection of patients with tuberculosis of the lungs]. / Fermenty limfotsitov, aktivnost' protsessov perekisnogo okisleniia lipidov i antioksidantnoi zashchity u bolnykh tuberkulezom legkikh.

Activity of succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, NAD2- and NADP2-diaphorases and acid phosphatase in lymphocytes of the peripheral blood as well as malonic dialdehyde and alpha-tocopherol, as parameters of lipid peroxidation defense, were studied in 49 patients with different forms of pulmonary tuberculosis and in 17 practically and clinically healthy subjects. Patients with focal pulmonary tuberculosis presented drop of succinate dehydrogenase and NAD2-diaphorase activity and rise of alpha-glycerophosphate dehydrogenase and NADP2-diaphorase activity in lymphocytes. Parameters of malonic dialdehyde and alpha-tocopherol in patients and healthy subjects had no difference. Patients with infiltrative and fibrocavernous pulmonary tuberculosis had drastic suppression of energy enzymes and sharp rise of acid phosphatase activity in lymphocytes, which correlated with a significant rise of malonic dialdehyde level and decrease of blood serum alpha-tocopherol. There was a tendency to an increase in energy enzymes activity and decrease of acid phosphatase activity 3-4 months after chemotherapy, which was followed by the clinical improvement of patients' condition. Direct dependence was found between the normalization of enzyme activity of lymphocytes and diminution of lipid peroxidation processes.

[Possibilities of intravenous use of helium-neon laser in the treatment of experimental tuberculosis of animals]. / Vozmozhnosti vnutrivennogo ispol'zovaniia gelii-neonovogo lazera pri lechenii éksperimental'nogo tuberkuleza zhivotnykh.

The study presents experimental finding of 40 mongrel dogs whose intravascular blood was irradiated with laser as a supplement to the multimodality treatment of respiratory tuberculosis. Earlier disappearance of intoxication symptoms and reduced terms of destruction cavity decrease and closure, as roentgenologically evidenced, was achieved. The influence of this treatment on certain lipid peroxidation parameters, hemocoagulation, immunity status and bacteriostatic blood activity were found. There were no side effects during treatment.

[Biochemical mechanisms of neurotoxic reactions to antibacterial preparations in patients with pulmonary tuberculosis]. / Biokhimicheskie mekhanizmy neirotoksicheskikh reaktsii na antibakterial'nye preparaty u bol'nykh tuberkulezom legkikh.

Examination comprising the electrophysiologic method and study of the biochemical parameters of the antioxidant/lipid peroxidation system and metabolism of biologic amines in 163 patients with infiltrative pulmonary tuberculosis has revealed a clear interaction existing between the functional changes of the CNS state, the state of antioxidative defense (alpha-tocopherol) and serotonin. This allows an assumption that the antioxidant/lipid peroxidation system and serotoninergic system actively participate in the pathogenesis of development of neurotoxic reactions to antibacterial preparations in the clinical picture of tuberculosis.

[Functional disorders of the central nervous system in patients with pulmonary tuberculosis]. / Narusheniia funktsional'nogo sostoianiia tsentral'noi nervnoi sistemy u bol'nykh tuberkulezom legkikh.

Two groups of pulmonary tuberculosis patients were followed up to reveal the relation between the lipid peroxidation (LPO) processes and the function of the central nervous system (CNS) in pulmonary tuberculosis. Group 1 (n = 76) included subjects with normal baseline electroencephalographic findings; group 2 (n = 41) consisted of those with profound changes in the electroencephalogram. The findings of LPO processes were assessed by the blood levels of malonic dialdehyde and alpha-tocopherol. Group 2 showed a direct relationship between the progression of neurotic symptoms and the abnormal changes in the values of LPO processes. It is concluded that it is expedient to use antioxidants in the combined treatment of pulmonary tuberculosis patients to eliminate the baseline CNS changes caused by the specific process.

[The pro-fibrotic and pro-oxidant action of isoniazid]. / Profibroticheskoe i prooksidantnoe deistvie izoniazida.

As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue. Two mechanisms of isoniazid's pro-fibrotic action are presented.

[Mechanism of the hypotensive effect of sodium oxybutyrate in pulmonary hypertension in experimental tuberculosis in dogs]. / O mekhanizme gipotenzivnogo deistviia oksibutirata natriia pri legochnoi gipertenzii u zarazhennykh tuberkulezom sobak.

The mechanism of sodium oxybutyrate effect on the lung vessels under normal conditions and under conditions of experimental tuberculosis in dogs was studied by the time course of pressure in the pulmonary artery and the content of serotonin, histamine and adenosine in blood of the aorta and pulmonary artery after the drug intravenous administration. To confirm the antihypoxic effect of sodium oxybutyrate, the levels of lactate, pyruvate, ATP, ADP and AMP were investigated. The levels of adenosine were judged indirectly by the activity of 5-nucleotidase, adenosine desaminase and AMP. It was shown that the decrease in pressure in the pulmonary artery after the use of sodium oxybutyrate was connected with the drug antihypoxic effect which led to lower levels of histamine in the aorta blood under the normal conditions and to higher levels of adenosine under the conditions of tuberculosis.