[The testing of the carcinogenicity of dispirotripiperazine derivatives by combined administration with sodium nitrite]. / Testirovanie kantserogennosti proizvodnykh dispirotripiperaziniia pri kombinirovannom vvedenii s nitritom natriia.

The cancerogenic activity of the dispirotripiperasinium derivatives prospidine and spirobromine was tested in concurrent use with sodium nitrite. The drugs were intragastrically administered once a week. It was combined with sodium nitrite, 35 mg/kg, to non-inbred rats of both sex during 24 months. A morphological study revealed no statistically significant reduction of latency and no increase in the incidence of tumors in laboratory animals. No cancerogenic effect of sodium nitrite was found.

[Effect of piracetam on rat reproductive function and the sexual development of their progeny]. / Vliianie piratsetama na reproduktivnuiu funktsiiu krys i polovoe razvitie potomstva.

Administration of piracetam to infantile rats in a daily dose of 100 mg/kg for 10 days caused acceleration of sexual maturation of females and a slight delay of maturation of males. Antenatal administration of the same dose of piracetam exerted a depressive action on the development of the organs of the reproductive system in males from the offspring with a simultaneous increase in the pituitary gonadotropic activity.