ABSTRACT
In this paper we have showed that evolutionary new genes DCD1(Dermicidin), LINC00309 (Long intergenic non-protein coding RNA 309) and CLLU1(Chronic lymphocytic leukemia up-regulated 1) have tumor-specific expression profile. Along with our previously published results this confirms the existence of the phenomenon of TSEEN (Tumor-Specifically Expressed, Evolutionarily Novel).
Subject(s)
Neoplasm Proteins/genetics , Neoplasms/genetics , Peptides/genetics , RNA, Long Noncoding/genetics , Biomarkers, Tumor/genetics , Evolution, Molecular , Female , Gene Expression Regulation, Neoplastic , Humans , Male , Neoplasms/classification , Neoplasms/pathologyABSTRACT
A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
