1.
Res Commun Chem Pathol Pharmacol
; 15(2): 279-90, 1976 Oct.
Article
in English
| MEDLINE
| ID: mdl-185672
ABSTRACT
A series of in vitro experiments using pregnenolone-14C-4 and progesterone-14C-4 as precursors were performed to determine the effects of prolonged ACTH administration on adrenal steroid biogenesis in the rat. Under ACTH administration there was a tendency for the isolated steroids to have larger quantities and specific activities from both precursors than under control conditions. In contrast to the rabbit, the rat did not produce any detectable amounts of 17 alpha-hydroxylated steroids under either control or prolonged ACTH treatment using the very sensitive double isotope derivative assay for quantitation.
Subject(s)
Adrenal Glands/metabolism , Adrenocorticotropic Hormone/pharmacology , Steroids/biosynthesis , Adrenal Glands/drug effects , Animals , In Vitro Techniques , Male , Pregnenolone/metabolism , Progesterone/metabolism , Rats , Swine , Time Factors
2.
Endocrinology
; 93(3): 517-26, 1973 Sep.
Article
in English
| MEDLINE
| ID: mdl-4352801
Subject(s)
17-Hydroxycorticosteroids/biosynthesis , Adrenal Glands/drug effects , Adrenocorticotropic Hormone/pharmacology , 11-Hydroxycorticosteroids/biosynthesis , Acetylation , Adrenal Glands/metabolism , Aldosterone/biosynthesis , Animals , Body Weight/drug effects , Carbon Isotopes , Chromates , Chromatography, Paper , Corticosterone/biosynthesis , Desoxycorticosterone/biosynthesis , Male , Organ Size , Oxidation-Reduction , Pregnenolone/metabolism , Progesterone/metabolism , Rabbits , Tritium
3.
Proc Soc Exp Biol Med
; 143(4): 1201-6, 1973 Sep.
Article
in English
| MEDLINE
| ID: mdl-4743699
4.
Arch Biochem Biophys
; 121(2): 331-5, 1967 Aug.
Article
in English
| MEDLINE
| ID: mdl-6057102
5.
J Atheroscler Res
; 6(3): 283-91, 1966.
Article
in English
| MEDLINE
| ID: mdl-5941776
