ABSTRACT
In a study the case of an acute intoxication following inhalant abuse of trichloroethylene vapours is presented. Narcotic effects lasting for 48 hours after exposure were seen. The patient complained of strong, polyneuropathic lower legs and feet pain lasting for 7 days. Urinary trichloroacetic acid (TCA) was monitoring. Peak urine TCA concentration reached 840 mg/L on 4 day after exposure.
Subject(s)
Pain/prevention & control , Poisoning/diagnosis , Psychoses, Substance-Induced/etiology , Solvents/poisoning , Trichloroethylene/pharmacokinetics , Trichloroethylene/poisoning , Adjustment Disorders/complications , Administration, Inhalation , Adult , Alcoholic Intoxication/complications , Critical Care , Drug Synergism , Electrocardiography , Ethanol/blood , Ethanol/pharmacokinetics , Ethanol/poisoning , Foot/physiopathology , Humans , Leg/physiopathology , Lethal Dose 50 , Male , Maximum Allowable Concentration , Monitoring, Physiologic , Pain/chemically induced , Poisoning/therapy , Polyneuropathies/chemically induced , Solvents/analysis , Solvents/pharmacokinetics , Treatment Outcome , Trichloroacetic Acid/pharmacokinetics , Trichloroacetic Acid/urine , Trichloroethylene/urineABSTRACT
We present the case of 20-year-old woman intoxicated with mixed drugs, composed of paracetamol (acetaminophen), ferrous sulphate, naproxen and benzodiazepines. Acute toxic liver damage with clinical symptoms of coma resolved at the patient. Lack of the past history doesn't let to specific therapy and systemic complications. In this data we confirm, that past history, clinical symptoms and laboratory results are needed in designing a treatment strategy.
Subject(s)
Acetaminophen/poisoning , Benzodiazepines/poisoning , Chemical and Drug Induced Liver Injury/complications , Ferrous Compounds/poisoning , Hepatic Encephalopathy/etiology , Liver Failure, Acute/chemically induced , Naproxen/poisoning , Adult , Chemical and Drug Induced Liver Injury/etiology , Female , Hepatic Encephalopathy/diagnosis , Hepatic Encephalopathy/therapy , Humans , Liver Failure, Acute/diagnosis , Liver Failure, Acute/therapy , Treatment OutcomeABSTRACT
Suicidal attempt with old (currently unused) drug is described. The suicidal attempts are usually performed with the use of contemporary pharmacotherapeutics. In the report a case of suicidal attempt with old drug Tardyl is presented. Tardyl (Glutethimid) was prescribed to the patient and has been stored for 20 years. The patient was previously treated for depression and many suicidal attempts. In the course of intoxication: balance disturbances, psychomotor retardation, changes in consciousness with temporary excitation were observed. The concentration of glutethimid in the urine was 1.1 mg% and 0.5 mg% in the blood. Patient was treated according to the general rules of intensive care. After 4 days of therapy the patient improved and was transferred to psychiatric unit in Koscian.
