Subject(s)
Fingers , Neoplasms, Squamous Cell/diagnosis , Neoplasms, Squamous Cell/virology , Papillomaviridae/isolation & purification , Skin Neoplasms/diagnosis , Skin Neoplasms/virology , Adult , Amputation, Surgical , Female , Fingers/pathology , Fingers/surgery , Humans , Neoplasms, Squamous Cell/therapy , Skin Neoplasms/therapy , Warts/complicationsABSTRACT
A patient is presented who used apomorphine, a potent dopamine agonist in the treatment of Parkinson patients. He suffered of severe dystonia of the legs, which did not respond to conservative treatment. The apomorphine was delivered bij intranasal spray. The patient developed an allergic reaction with swollen nose and lips, which disappeared within one day after discontinuation of the treatment. Subcutaneous administration caused no symptoms. Cutaneous challenge with apomorphine caused a positive reaction. We raise the hypothesis that the allergic reaction was due to the binding of apomorphine to certain proteins in cutis or nasal mucosa.
Subject(s)
Angioedema/chemically induced , Apomorphine/adverse effects , Parkinson Disease/drug therapy , Administration, Intranasal , Apomorphine/administration & dosage , Humans , Injections, Subcutaneous , Lip , Male , Middle Aged , NoseABSTRACT
We report the cases of four patients who were taking the anticonvulsant drugs phenytoin or carbamazepine and in whom skin lesions developed that showed histologic features suggestive of mycosis fungoides. Two patients had a solitary lesion on the trunk, whereas the other two patients had multiple plaques. In all four patients systemic signs were absent.
Subject(s)
Carbamazepine/adverse effects , Drug Eruptions/etiology , Mycosis Fungoides/pathology , Phenytoin/adverse effects , Skin Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Diagnosis, Differential , Drug Eruptions/pathology , Epilepsy/drug therapy , Female , Humans , Male , Mycosis Fungoides/diagnosis , Skin Neoplasms/diagnosis , T-Lymphocytes/pathology , T-Lymphocytes/ultrastructureABSTRACT
A 63-year-old female with the classical clinical and histological features of malignant angioendotheliomatosis with disease limited to the skin is reported. Immunohistochemical studies revealed the presence of an intravascular large cell lymphoma of B cell origin. The recent literature regarding the histogenesis and nomenclature of this disease is reviewed.
Subject(s)
Hemangioendothelioma/diagnosis , Lymphoma/diagnosis , Skin Neoplasms/diagnosis , Antigens/immunology , Diagnosis, Differential , Factor VIII/immunology , Female , Histocompatibility Antigens/immunology , Humans , Leukocyte Common Antigens , Lymphoma/immunology , Lymphoma/pathology , Middle Aged , Skin Neoplasms/immunology , Skin Neoplasms/pathology , von Willebrand FactorABSTRACT
Thirty-five ophthalmological patients with symptoms of contact allergy due to external eye medication were examined with patch tests in the dermatological outpatient department. Attention is paid to sensitization due to antibiotics, in particular Neomycin.
Subject(s)
Anti-Bacterial Agents/adverse effects , Drug Hypersensitivity/diagnosis , Administration, Topical , Anti-Bacterial Agents/administration & dosage , Humans , Neomycin/administration & dosage , Neomycin/adverse effects , Ointments/adverse effects , Ophthalmic Solutions/adverse effects , Patch TestsABSTRACT
A case of systemic lupus erythematosus, complicated by a systemic cryptococcal infection with involvement of the skin is described.
