ABSTRACT
We studied the effect of antioxidant therapy on the state of glutathione system in erythrocytes in patients with stage 1, 2, and 3 circulatory encephalopathy treated with antioxidant cytoflavin against the background of basic therapy (kavinton and pyracetam). It was demonstrated that the response of the erythrocyte glutathione system to antioxidant therapy was quantitatively and qualitatively different at different stages of cerebrovascular failure, which was related to changes in the glutathione system during the development of chronic cerebral ischemia. Endogenous reserve of the antioxidant defense system should be taken into account when prescribing antioxidant therapy; the glutathione system can be a marker of this reserve.
Subject(s)
Antioxidants/therapeutic use , Brain Ischemia/drug therapy , Erythrocytes/metabolism , Glutathione/blood , Adult , Brain Ischemia/metabolism , Chronic Disease , Female , Humans , Male , Middle AgedABSTRACT
Prophylactic dietary intake of synthetic ubiquinone-10, succinic acid, or mixture of these substances prevented disturbances in aggregation and electrophoretic mobility of erythrocytes and inhibited lipid peroxidation in cells of rats with experimental epinephrine-induced toxemia.
Subject(s)
Epinephrine/toxicity , Erythrocytes/drug effects , Succinic Acid/pharmacology , Toxemia/blood , Ubiquinone/pharmacology , Animals , Erythrocyte Aggregation/drug effects , Erythrocytes/metabolism , Female , Hypoxia , Lipid Peroxidation , Models, Biological , Rats , Toxemia/metabolismABSTRACT
The use of synthetic ubiquinone-10 (2 and 10 mg/kg) as a therapeutic food additive normalized the counts of erythrocytes, reticulocytes, and leukocytes and the content of hemoglobin in the blood and inhibited lipid peroxidation in erythrocytes in irradiated rats (3 Gy).
