ABSTRACT
We studied the effect of biologically active substances derived from hydrobionts, namely maristim (natural product from sea urchin roe) and fucolam (polysaccharides of fucoidan and calcium alginate from brown algae) on blood biochemistry in the mouse model of nutritional hypercholesterolemia. Maristim and fucolam are found to be capable to normalize the levels of the major indicators of lipid and carbohydrate metabolism and aminotransferase enzyme activity in terms of atherogenic load. Correction action of biologically active substances is more expressed in combined application. Identified experimentally normalizing effects of maristim and on lipid and carbohydrate metabolism allow us to recommend the further study in clinical trials of these biologically active substances and based on them additives.
Subject(s)
Biological Products/pharmacology , Carbohydrate Metabolism/drug effects , Complex Mixtures/pharmacology , Hypercholesterolemia/metabolism , Lipid Metabolism/drug effects , Polysaccharides/pharmacology , Alginates/pharmacology , Animals , Blood Chemical Analysis , Carbohydrate Metabolism/physiology , Diet, Atherogenic , Glucuronic Acid/pharmacology , Hexuronic Acids/pharmacology , Hypercholesterolemia/etiology , Lipid Metabolism/physiology , Mice , Pacific Ocean , Phaeophyceae/chemistry , Sea Urchins/chemistry , Transaminases/metabolismABSTRACT
Antioxidants of natural origin are considered as possible agents for prevention and treatment of liver diseases. Marine algae and in particular their extracts and obtained from them sulfated polysaccharides are significant sources of natural antioxidants. The recent data on the effect of the extracts and sulfated polysaccharides of seaweed on the functional activity of the liver with injuries induced by CCl4, some drugs (paracetamol, diclofenac), N-nitrosocompounds, aflatoxin are presented in the review. Particular attention is paid to the effect of sulfated polysaccharides and in particular fucoidans on the functional activity of the liver in patients with chronic viral hepatitis C. Fucoidan is highly safe and active not only as an antioxidant but also as an inhibitor of HCV replication, has antiinflammatory and immunomodulating effects. The data of the review allow to conclude that seaweed extracts and sulfated polysaccharides may be a basis for development of new generation drugs in the future for the treatment and prevention of liver diseases.
Subject(s)
Antioxidants/pharmacology , Chemical and Drug Induced Liver Injury/drug therapy , Hepatitis C, Chronic/drug therapy , Immunologic Factors/pharmacology , Polysaccharides/pharmacology , Seaweed/chemistry , Acetaminophen , Aflatoxins , Animals , Antioxidants/isolation & purification , Carbon Tetrachloride , Diclofenac , Hepatitis C, Chronic/virology , Humans , Immunologic Factors/isolation & purification , Nitroso Compounds , Polysaccharides/isolation & purificationABSTRACT
The effects of the small doses of the preparation Gistochrome, containing natural polyhydroxynaphtoquinoine echinochrom A from flat sea urchin Scaphechinus mirabilis, on blood biochemical parameters have been studied in patients with cardiovascular diseases. Gistochrome administration influenced the LPO-antioxidant protection system, indicating reinforcement of antioxidant protection mechanisms. Gistochrome modulated the immune status and the plasma cytokine profile. Thus, Gistochrome may be recommended as means of additional therapy for patients with cardiovascular diseases for correcting the metabolic, immunological and redox impairments.
Subject(s)
Antioxidants/therapeutic use , Atherosclerosis/blood , Hypertension/blood , Immunologic Factors/therapeutic use , Myocardial Ischemia/blood , Naphthoquinones/therapeutic use , Animals , Antigens, CD/metabolism , Antioxidants/isolation & purification , Atherosclerosis/drug therapy , Atherosclerosis/physiopathology , Blood Cell Count , Case-Control Studies , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Cholesterol, VLDL/blood , Cytokines/metabolism , Humans , Hypertension/drug therapy , Hypertension/physiopathology , Immunologic Factors/isolation & purification , Injections, Intramuscular , Lipid Peroxidation/drug effects , Malondialdehyde/blood , Middle Aged , Myocardial Ischemia/drug therapy , Myocardial Ischemia/physiopathology , Naphthoquinones/isolation & purification , Oxidation-Reduction/drug effects , Sea Urchins/chemistry , Triglycerides/bloodABSTRACT
The efficacy of a novel synbiotic drink in the complex therapy of patients withchronic diseases of the gastrointestinal tract and concominant intestinal dysbacteriosis was investigated in a randomized trial. The synbiotic drink contains a probiotic strain of bifidobacteria and Fucus evanescens polysaccharides with prebiotic activity and broad spectrum of the biological action on the patients. The use of the synbiotic drink provided more evident reduction of the clinical symptomes, more efficient recovery of the intestinal microflora and higher percentage of the patients cure vs. the routine therapy and the therapy with inclusion of sour milk bifidobacterin.
