ABSTRACT
The objective of the present study was to evaluate the efficiency of the method designed to adapt women with menopausal metabolic syndrome to periodic hypobaric hypoxia. The patients (68 women at a mean age of 52.8 +/- 1.1 years with menopausal metabolic syndrome) were adapted to hypobaric hypoxia in an Ural-1 low-pressure chamber (twenty two daily 3-hour sessions at a simulated "altitude" of 3,500 m above sea level equivalent to 460 mm Hg). The treatment resulted in a significant decrease of modified menopausal index and body weight (by 53.5% and 6.1% respectively). Moreover, systolic and diastolic blood pressure was reduced by 13.4% and 7.3% while the levels of plasma cholesterol, glucose, and insulin dropped by 19.5%, 21.3%, and 20.2% respectively. The results of the study demonstrate high efficacy of the method of adaptation to periodic hypobaric hypoxia and the possibility of its application for the correction of clinical and metabolic disturbances in postmenopausal women.
Subject(s)
Atmospheric Pressure , Hypoxia/physiopathology , Menopause , Metabolic Syndrome/therapy , Blood Pressure/physiology , Body Mass Index , Cholesterol/blood , Female , Glucose Tolerance Test , Humans , Hypoxia/blood , Hypoxia/metabolism , Menopause/metabolism , Metabolic Syndrome/blood , Metabolic Syndrome/etiology , Metabolic Syndrome/physiopathology , Middle Aged , Treatment Outcome , Triglycerides/bloodABSTRACT
AIM: To assess efficacy of adaptation to periodic hypobaric hypoxia (PHH) in the treatment of postmenopausal women with arterial hypertension (AH). MATERIAL AND METHODS: The method of adaptation to PHH in the pressure chamber Ural-1 (22 three-hour daily sessions, pressure 460 mmHg) was used in 46 postmenopausal AH women (mean age 53.8 +/- 3.9 years). The method was assessed for effects on blood pressure (BP), symptoms of menopausal syndrome, body mass, levels of some hormones, lipid and carbohydrate metabolism. RESULTS: Adaptation to PHH reduced systolic pressure by 13.9%, diastolic one--by 8.2%, the levels of follicule stimulating and luteinising hormones by 26.8 and 21.5%, respectively, cholesterol--by 14.7, glucose--by 21.3, insulin--20.2%; estradiol and dehydroepiandrosteron sulphate concentrations rose by 19.3 and 15.2%, respectively. CONCLUSION: Adaptation to PHH produced an antihypertensive effect and a positive trend in clinicometabolic indices in AH women in postmenopause.
