[Effect of TLT absorptive eyeglasses on progression of myopia in children]. / Vliv absorpcních brýlových skel TLT na progresi krátkozrakosti u detí.

The incidence of myopia is increasing worldwide. At the last VIIIth international conference on myopia held in June 2000 in Boston attention was aroused by the work of Quin et al. on the influence of noctural illumination in rooms where children slept on their subsequent development of myopia. Our working hypothesis presented in Hakone in 1996 presumes also a negative effect of light and heat which initiate the development of myopia but on eyes with an inborn disposition. We considered as a solution wearing spectacles with glass which allow to penetrate only visible light and absorb the other wavelengths. These glasses were supplied by Karel Kubena-TL Technologies. The authors followed up for four years two groups of children with progressive myopia. The progression of myopia during the first two years of the follow up was almost identical in the two groups: in the group with the absorption glasses 0.75 D/year and in the control group 0.77 D/year. After two years of wearing the absorption glasses the progression in the group with the absorption glasses was 0.34 D/year and in the control group 0.59 D/year.

[The optic nerve disk in myopic children with elevated intraocular pressure]. / Terc zrakového nervu u krátkozrakých detí s vyssím nitroocním tlakem.

The optic nerve disc of short-sighted children with elevated intraocular pressure was investigated to achieve early assessment of glaucoma and to detect signs which differentiate changes in the disc caused by short-sightedness from changes caused by glaucoma. The authors examined 16 eyes of 8 short-sighted children with elevated intraocular pressure. In addition to the basic ophthalmological examination they made a digital analysis of the optic nerve disc incl. planimetric evaluation of the dimensions of the disc, excavation and the neuroretinal rim. In two patients despite the higher intraocular pressure the area of the rim was supraliminal. In three patients the narrower area of the neuroretinal rim increased the probability of glaucoma In two patients with anisometropia on the eye with greater myopia the intraocular pressure was higher and the neuroretinal rim narrower as compared with the other eye. In one patient the area of the rim was very narrow and the diagnosis of glaucoma was confirmed also by arcuate scotoma in the lower part of the visual field corresponding to the narrow rim on top.

[Effect of infrared rays on the eye in progressive myopia]. / Vliv infracerveného zárení na oko s progresivní krátkozrakostí.

In the submitted paper the authors pay attention to infrared radiation close to visible light is intensely absorbed by haemoglobin, melanin and xanthophyll whereby part of the radiation energy is transformed into heat. The authors present three series of experiments where they investigated by different methods changes in the vitreous body after exposure to light, infrared radiation or raised temperature. They assume that on the defocused eye with a myopic conus which developed as a result of an inborn inadequate closure of the optic cup the light can cause a rise of temperature in the vitreous body. This leads to metabolic changes characterized by increased activity of lysosomal enzymes causing loss of the spatial structure of hyaluronic acid and collagen biomolecules. Penetration of the altered vitreous fluid thought the conus can lead to degradation of the interstitial substances of the sclera. Suitable absorption glasses filtering infrared light close to visible light could reduce the hyperthermia of the vitreous body.

[Visual perceptions in ophthalmic migraine]. / Zrakové vjemy pri oftalmické migréne.

The number of patients with ophthalmic migraine is steadily increasing. The symptoms of their attacks are dominated by typical visual aura, followed by major or minor headache. The authors present the experience of three physicians who observed the symptoms on themselves. The first one has suffered from the disease already for fifty years, the second and third one 25 years each. In the discussion the authors deal with the differential diagnosis of the disease and its possible treatment.

Nutrition and the immune system: a review of nutrient-nutrient interactions.

Although research on the role of single nutrients in immune function is extensive, this is not the case for multiple nutrients and subsequent nutrient-nutrient interactions. After presenting a brief overview of immune function, the authors consider reports that examine imbalance of more than one nutrient and interactive effects on immunocompetence. Availability of one nutrient may impair or enhance the action of another in the immune system, as reported for nutrients such as vitamin E and selenium, vitamin E and vitamin A, zinc and copper, and dietary fatty acids and vitamin A. Nutrient-nutrient interactions may negatively affect immune function. For example, excess calcium interferes with leukocyte function by displacing magnesium ions, thereby reducing cell adhesion. Because of consumer interest in supplementation to improve immune function, the potential for harm exists. Research is needed to improve knowledge in this area so that recommendations can be made with more confidence.

Blood lipids, cardiovascular fitness, obesity, and blood pressure: the presence of potential coronary heart disease risk factors in adolescents.

OBJECTIVE: To identify and compare the presence of coronary heart disease (CHD) risk factors among 14- and 15-year-old boys and girls. DESIGN: For this cross-sectional study of 54 subjects, a blood sample taken after subjects fasted was used to determine total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations. Dietary intake was estimated using a 24-hour recall and a 2-day food record. Height, weight, and skinfold thicknesses were measured to identify obese and severely obese subjects. Cardiovascular fitness, blood pressure, and cigarette use also were measured. TC, HDL-C, LDL-C, fitness, blood pressure, and smoking are modifiable risk factors, for CHD. SUBJECTS: Adolescents were selected by random sampling from lists of students attending public schools in two central Texas cities. Adolescents who were 14 or 15 years old; were not pregnant; and had no history of high blood pressure, diabetes, or heart disease were eligible to participate. STATISTICAL METHODS: Data were analyzed using Student's t and chi square tests. RESULTS: Of the subjects, 25% demonstrated two or more risk factors for CHD. A significantly higher percentage of girls than boys had a TC concentration greater than 5.2 mmol/L. Boys (n=29) had a mean fitness score that indicated a higher level of cardiovascular fitness than girls (n=25); however, the mean score for both groups was below average. CONCLUSION: Data provide support for increased interventions targeted toward lowering the risk factors for CHD and other chronic diseases in adolescents.

Factors associated with sources of influence/information in reducing red meat by elderly subjects.

A number of studies have found that health beliefs and social influences predict changes in dietary intake, including red meat. These studies have not determined what kinds of individuals are more likely to change their diets due to the advice of physicians, the advice of significant others, or because of mass-media exposure. We obtained data from 424 elderly Houstonians regarding whether they had attempted to reduce red meat consumption and if so, why. Social network, health status, food attitude and demographic variables are used to differentiate those who have made physician-induced changes from other sources of influence/information for change. Elderly subjects with smaller abdominal girth measurements are more likely to make red meat reductions regardless of the source of influence/information; those who believe in the efficacy of health foods are more likely to give physicians and mass media as sources of influence/information for red meat reductions. Men are more likely than women to report red meat reductions because of mass media and physician influences. Women who receive a greater amount of companionship from their social networks are more likely to change because of friends/relatives influences.

The relationship of nutritional copper to the development of postmenopausal osteoporosis in rats.

Factors that influence tissue copper concentration include age, diet, hormones, and pregnancy. In this study we altered diet independently, hormone (estrogen) independently, and various combinations of diet and hormone in animals of the same age to study the effects of ovariectomy complicated with dietary copper deficiency; a deficiency that has been demonstrated to cause bone defects. Sprague-Dawley rats were placed on various combinations of copper deficient or enriched diets before and/or after ovariectomy to determine if copper deficiency aggravated osteoporosis and if return to a copper-adequate diet alleviated it. In this study, ovariectomy did induce an osteopenia that was characterized by decreased trabecular bone. This osteopenia was slightly more severe with copper deficiency, but was not necessarily alleviated by the return of normal copper levels to the diet.

n-3 fatty acid enriched table eggs: a survey of consumer acceptability.

Table eggs enriched with n-3 fatty acids may provide an alternative to fish as a source of these proposed healthful fatty acids. Successful marketing of this product may be influenced, however, by consumer perceptions of the egg as an unhealthful food. Therefore, the objectives of the current study were to assess consumer perceptions of table egg health quality and to determine the potential consumer acceptability of an n-3 fatty acid-enriched table egg. A survey was conducted in five major Texas cities; over 500 consumers completed the survey. Data were analyzed using the chi-square procedure. The majority of consumers surveyed considered eggs healthful and reported purchasing eggs at least once monthly and consuming an average of three whole eggs per week, as compared with an average reported fish consumption of only one serving per week. Sixty-five percent of the consumers reported willingness to purchase an n-3 fatty acid-enriched table egg and of these, 71% were willing to pay an additional $.50 per dozen. These data indicate that n-3 fatty acid-enriched table eggs represent a viable means of incorporating n-3 fatty acids into the diet of health-conscious consumers.

Physicians' knowledge of dietary fat and advice to patients.

A mailed survey of 239 Texas physicians selected by a stratified random sample was completed in 1990 (response ratio = 39.5%) concerning physician's background in nutrition, nutrition knowledge, and recommended treatments to patients with hypercholesterolemia. Twenty-one percent reported taking a nutrition seminar and 41 percent read a nutrition text during the past year. Less than a third had taken a nutrition course after medical school; half had taken such a course during medical school. Over 46 percent achieved a perfect score on nine knowledge questions regarding dietary fat. Only 35 percent identified the latest American Heart Association nutrition education effort. Seventy-four percent said they ate chicken or fish instead of red meat three or more times a week. Over 80 percent selected exercise, weight reduction, and low fat diets as the most important treatment types. Physicians continue to have limited knowledge of nutrition and should be encouraged to make greater use of dietitians as consultants.

Effect of butter, mono- and polyunsaturated fatty acid-enriched butter, trans fatty acid margarine, and zero trans fatty acid margarine on serum lipids and lipoproteins in healthy men.

The effect of diets containing 50% of fat calories from butter, butter enriched with mono- and polyunsaturated fatty acids, and margarines with and without trans fatty acids on the serum lipids of 38 healthy men in a free-living condition have been determined. Serum lipid responses to the high level of individual dietary fats were unexpectedly small. The butter diet produced a small, but significant rise (5%) in the total serum cholesterol and low density lipoprotein (LDL)-cholesterol, relative to all other diets. Enrichment of butter with either olive oil (50/50) or sunflower oil (50/50) failed to reduce serum lipid levels below habitual diet values. Hard margarine, containing 29% trans fatty acids, caused a decrease in apolipoprotein A-I and B levels, but did not change total serum cholesterol or LDL-cholesterol levels, relative to habitual diet values. A soft margarine, high in linoleate, with no trans fatty acids reduced total cholesterol, LDL-cholesterol, and apolipoprotein B significantly, relative to all diets. Soft margarine high density lipoprotein (HDL)-cholesterol levels remained unchanged, but apolipoprotein A-I values were decreased relative to habitual and butter diets. The quantities of saturated fatty acids and the sum of monounsaturated and polyunsaturated fatty acids consumed on the hard and soft margarines were equal; therefore, the different response of serum cholesterol and LDL-cholesterol between these two diets is attributable to the trans fatty acids in the hard margarine. The data indicate that trans fatty acids are not metabolically equivalent to the natural cis isomers and that they affect the serum lipid profile adversely.

Life events, social support, and immune response in elderly individuals.

One hundred ninety-two elderly men and women were investigated to determine the effects of recent life events, psychological adjustment, and social support on lymphocyte count, controlling for nutritional status, age, education, income, and the presence of lymphocyte-altering drugs. Effects of specific recent life events were found. For elderly males, recent sexual dysfunction lowers lymphocyte count, while psychological adjustment and percentage kin in the intimate network elevates it. For elderly females, the experience of either family or legal problems elevates lymphocyte count as does frequent interaction with members of the intimate network. These results suggest that life events have very different effects on elderly men and women's immune systems. Social support has direct but mediating effects on lymphocyte count for both genders.

Modification of plasma and hepatic lipids of guinea pigs by feeding high oleic acid pork compared with regular pork.

Meat from such monogastric animals as swine can be modified to substitute monounsaturated fatty acids for saturated fatty acids. Because monounsaturated fatty acids have a beneficial effect on serum lipids as compared with saturated fatty acids, the objective of this study was to assess the effect of modified pork as compared with regular pork on serum and hepatic lipids. Guinea pigs were fed diets containing pork from control diet-fed hogs or from hogs fed a diet containing high oleic acid sunflower oil. The pork provided almost all of the fat in the diets at the level of 4 and 15 g/100 g diet, 10 or 34% energy. The high oleic pork muscle and fat contained 26 and 46% less palmitic and stearic acids (the primary saturated fatty acids), respectively, and 31 and 29% more oleic acid (the primary monounsaturated fatty acid) than the regular pork muscle and fat, respectively. Cholesterol concentration of diets ranged from 0.06 to 0.08% of the diet. Although total serum cholesterol, HDL cholesterol and triglyceride concentrations did not differ due to type of pork, results indicated that serum LDL cholesterol was lower (15%) and hepatic cholesterol was greater (15%) in the high oleic pork, 15% fat group as compared with the control pork 15% fat group. Also, serum LDL cholesterol concentration was higher in the groups fed 15% fat compared with those fed 4% fat. In this study pork modified to have more oleic acid and less saturated fatty acids had a positive effect on tissue lipids when fed to animals.

[Collagen architecture of sclerocorneal trabeculae in relation to age]. / Kolagenní architektura sklerokorneálního trabekula v závislosti na veku.

The authors investigated the collagen architecture of the sclerocorneal trabeculum in relation to age in eight eyes within the range from a premature infant to a 90-year-old man. All specimens were investigated using a scanning electron microscope of Jeol Co. The appearance of fibrils does not change substantially in relation to age, however, their pattern and distribution change. In a 10-year-old boy Schlemm's canal is wide, oval with thin trabecular plates and wide open spaces surrounding them. In the 90-year-old man the canal is open but the plates on its luminous side are thickened, wrinkled and compressed. On the albuminous side there is a compact wall of compressed collagen layers.

Scleroplasty in progressive myopia--selection of materials.

Scleroplastic surgery is known to encounter the pathogenetical agent when the progressive myopia develops. In the first part, the implemented surgical approaches as well as up-to-date surgical techniques are presented. The experimental part is reserved for the selection of material which is necessary to perform scleroplasties. Both the allogenic and xenogenic grafts have been studied for histocompatibility on 20 rabbits. Following materials were used: 2 types of collagenic sponge, native and deproteinated human sclera, modified dura mater as well as both the native and devitalized sclera from rabbits. The best results were obtained with allogenic sclera, deproteinated xenogenic sclera and collagenic sponge. The application of other materials is discussed.

Anthropometry and health in the elderly.

Measurements of height, weight, skinfold thicknesses, and circumferences were obtained along with data on health practices and disease from 424 independent-living elderly in the Houston area. The objectives of the study were to examine anthropometric measurements of younger (58 through 74 years) and older (75 through 100 years) elderly individuals and to assess relationships between these measurements and health behaviors and disorders. Results demonstrated differences in anthropometric indexes due to aging and sex. Individuals who considered themselves to be more active than peers or who smoked had lower values for some anthropometric variables such as body mass index and waist circumference. Those who drank alcoholic beverages had lower values for some variables than those who stated that they did not drink alcohol. Diabetes and hypertension in the younger elderly were associated with higher values of some measurements, including waist circumference and body mass index. Anthropometric measurements in the elderly varied with sex, age, health practices, and the presence of certain disorders.

Progress in the development of a nutritional risk index.

The development of a 16-item nutritional risk index (NRI) is chronicled from its inception through its application in three studies designed to assess its reliability and validity. Study I involved a survey of 401 community-dwelling elderly in St. Louis, Missouri who were interviewed at baseline, 4-5 mo later, and 1 yr later. Study II involved a cross-sectional survey of 377 male outpatients attending two clinics at the St. Louis Veterans Administration Medical Center. Study III involved a cross-sectional survey of 424 community-dwelling elderly in Houston, Texas. Internal consistency reliability coefficients ranged between 0.47 and 0.60, and test-retest reliability coefficients ranged between 0.65 and 0.71. Validity was established by using the NRI to predict the use of health services, as well as by correlating it with a variety of anthropometric, laboratory, and clinical markers of nutritional status. The utility of the NRI for future applications is discussed.