ABSTRACT
A 49-year-old woman, who had fallen face first in a cactus 1 week earlier, presented with a small, mobile, noninflamed subcutaneous nodule at the rim of her right lateral orbit with no other functional deficits. A CT scan was obtained, which revealed a 4-cm intraorbital tubular-shaped foreign body resembling a large cactus spine. A second preoperative CT scan, obtained for an intraoperative guidance system, demonstrated a second cactus spine, which was initially not seen on the first CT scan. Both spines were removed surgically without complication. The authors discuss factors that can cause diagnosis delay, review the radiographic features of cactus spines, and discuss the often times benign clinical course of retained cactus spine foreign bodies. To the authors' knowledge, this is the first case report of cactus spines in the orbit. Health-care professionals should have a low threshold for imaging in cases of traumatic injuries involving cactus spines.
Subject(s)
Accidental Falls , Cactaceae/adverse effects , Eye Foreign Bodies/diagnostic imaging , Eye Injuries, Penetrating/diagnostic imaging , Orbit/injuries , Plant Structures/adverse effects , Eye Foreign Bodies/etiology , Eye Foreign Bodies/surgery , Eye Injuries, Penetrating/etiology , Eye Injuries, Penetrating/surgery , Female , Humans , Middle Aged , Ophthalmologic Surgical Procedures , Orbit/diagnostic imaging , Orbit/surgery , Tomography, X-Ray ComputedABSTRACT
OBJECTIVE: To evaluate the safety and efficacy of a new therapeutic agent, EPI-743, in Leber hereditary optic neuropathy (LHON) using standard clinical, anatomic, and functional visual outcome measures. DESIGN: Open-label clinical trial. SETTING: University medical center. Patients Five patients with genetically confirmed LHON with acute loss of vision were consecutively enrolled and treated with the experimental therapeutic agent EPI-743 within 90 days of conversion. Intervention During the course of the study, 5 consecutive patients received EPI-743, by mouth, 3 times daily (100-400 mg per dose). MAIN OUTCOME MEASURES: Treatment effect was assessed by serial measurements of anatomic and functional visual indices over 6 to 18 months, including Snellen visual acuity, retinal nerve fiber layer thickness measured by optical coherence tomography, Humphrey visual fields (mean decibels and area with 1-log unit depression), and color vision. Treatment effect in this clinical proof of principle study was assessed by comparison of the prospective open-label treatment group with historical controls. RESULTS: Of 5 subjects treated with EPI-743, 4 demonstrated arrest of disease progression and reversal of visual loss. Two patients exhibited a total recovery of visual acuity. No drug-related adverse events were recorded. CONCLUSIONS: In a small open-label trial, EPI-743 arrested disease progression and reversed vision loss in all but 1 of the 5 consecutively treated patients with LHON. Given the known natural history of acute and rapid progression of LHON resulting in chronic and persistent bilateral blindness, these data suggest that the previously described irreversible priming to retinal ganglion cell loss may be reversed.
Subject(s)
Optic Atrophy, Hereditary, Leber/drug therapy , Ubiquinone/analogs & derivatives , Adolescent , Blindness/etiology , Blindness/prevention & control , Child , Chromatography, High Pressure Liquid , Color Vision , Drug Approval , Emergency Medical Services , Eye/pathology , Female , Humans , Longitudinal Studies , Male , Middle Aged , Mitochondrial Diseases/complications , Optic Atrophy, Hereditary, Leber/genetics , Retina/pathology , Tandem Mass Spectrometry , Tomography, Optical Coherence , Ubiquinone/adverse effects , Ubiquinone/pharmacokinetics , Ubiquinone/therapeutic use , United States , United States Food and Drug Administration , Visual Acuity , Visual Field Tests , Young AdultABSTRACT
PURPOSE: To evaluate two checklist tools that are designed to guide, document, and assess resident training in strabismus surgery and examination of infants at risk for retinopathy of prematurity (ROP). METHODS: A panel of staff surgeons from several teaching institutions evaluated the checklists and provided constructive feedback. All former residents who had been trained via the use of these checklist tools were asked to take self-assessment surveys on competency in strabismus surgery and ROP examination. A Likert 5-point scale was used for all evaluations, with 1 being the lowest rating and 5 the highest rating. RESULTS: Six experts in strabismus and seven in ROP rated the checklists. Their comments were used to revise the checklists, which were sent to the same group for reevaluation. The mean Likert score for the final checklists was 4.9 of 5.0 for both checklists. Of 16 former residents, 9 responded to the self-assessments with a mean overall score of 4.1 (of 5.0) for strabismus surgery and 3.9 for ROP examination. CONCLUSIONS: These checklist tools can be used to assess the quality of a resident's training and experience in these specific ophthalmology skills. They are complementary to other curriculum and assessment tools and can serve to organize the educational experience while ensuring a uniformity of training.
