Macrophage activation syndrome triggered by active systemic lupus erythematosus : Successful treatment by interleukin-1 inhibition (anakinra).

This article presents a case of fulminant macrophage activation syndrome (MAS) as a rare complication of active systemic lupus erythematosus in a 33-year-old female patient. Initial presentation showed severe lupus disease exacerbation with renal involvement, hemolytic anemia, and neuropsychiatric changes. Early therapy focused on broad immunosuppression (high-dose corticosteroids and cyclophosphamide); however, disease remission could not be achieved. After an additional inflammatory focus and underlying malignancy were excluded, the triplet of pancytopenia, fever, and high ferritin levels indicated MAS, a bone marrow biopsy confirmed secondary hemophagocytic histiocytosis. Treatment with an interleukin­1 antagonist (anakinra) induced a fast, effective therapeutic success.

[Surgical treatment of 3- and 4-part fractures of the humeral head using a polyaxial-locking plate: results and patient satisfaction]. / Die polyaxial-winkelstabile Platte in der Versorgung von 3- und 4-Fragment-Frakturen des Humeruskopfs: objektive Ergebnisse und Patientenzufriedenheit.

INTRODUCTION: In recent years, new angle-stable plate implants with polyaxial screw direction were developed with the aim of an improved treatment of displaced 3- and 4-part fractures of the proximal humerus. There are only a few studies available about polyaxial implants in the treatment of 3- and 4-part proximal humerus fractures. Therefore, the aim of this study was to evaluate clinical results and complications of open reduction and internal fixation of displaced 3- and 4-part fractures using a polyaxial plate. PATIENTS AND METHODS: Within 51 months, 105 patients with a displaced 3- or 4-part fracture of the proximal humerus were treated with a polyaxial locking plate. The complications were evaluated and the Constant & Murley score was assessed and correlated with patient satisfaction ("very satisfied" to "not satisfied"). Additionally, the results were compared with those of monoaxial plates from the literature. Furthermore, the operative experience of the surgeons at the time of surgery was correlated with the objective results of the patients. RESULTS: 65 patients (average age: 71.3 ± 11.4 years; average follow-up: 19,6 ± 9,8 month [10-44 month]) with a displaced 3- or 4-part fracture were re-examined retrospectively (female: n = 54; male: n = 11). Overall, there were 27 3-part fractures and 38 4-part fractures. The Constant and Murley Score was on average 62.1 ± 16.5 points and the complication rate was 26 %. The most frequent complication was screw perforation through the humeral head. Patient satisfaction with clinical outcome was high within the whole study group. 40 % of the patients were "very satisfied" with their shoulder function, 29 % were "satisfied" ("fair": 12 %, "not satisfied": 19 %). Additionally, the operative experience of the surgeons influenced the final clinical result. CONCLUSION: In comparison to the literature we could not delineate better clinical outcomes or lower complication rates with polyaxial implants compared to monoaxial plates in 3- and 4-part fractures. Nevertheless, the majority of patients were satisfied with the clinical result in the context of age-related shoulder function. In addition, a close correlation could be detected between the degree of satisfaction and the objectively measured shoulder function. A high level of operative experience is required to avoid typical complications and to achieve a good clinical result.

Clinical outcome and complications using a polyaxial locking plate in the treatment of displaced proximal humerus fractures. A reliable system?

INTRODUCTION: The surgical treatment of displaced proximal humeral fractures (ORIF) is a perpetual challenge to the surgeon. For this reason, the principle of polyaxiality was developed to provide an improved primary stability of the fracture through better anchorage of the screws, especially in osteoporotic bone. The aim of this study was to present clinical results with the polyaxial locking plate in the operative treatment of proximal humerus fractures in order to determine whether the technique of polyaxiality leads to better functional outcome and lower complication rates in comparison to monoaxial plates in the literature. PATIENTS AND METHODS: Seventy-three patients with displaced proximal humeral fractures were treated surgically with the polyaxial locking Suture Plate™ (Arthrex(®)) between 03/2007 and 06/2009. Fifty-two of the patients (mean age, 69.9 ± 12.1) were included in a radiographical and clinical examination using the Constant score (CS) and the Disabilities of the Arm, Shoulder and Hand score (DASH). RESULTS: The follow-up examinations were on average 13.9 ± 4.5 months (10-27 months) after surgical treatment. The mean CS of the patients was 66.0 ± 13.7 points, the age- and gender-related CS was 90.9% ± 20.0% and the mean DASH score was 23.8 ± 19.8 points for the injured side. The patients with a nearly anatomical reduction of their fracture (n = 13) reached a significantly higher CS (75.1 ± 8.5; p = 0.004) and DASH-score (13.6 ± 11.6; p = 0.043) and none of these patients had a complication. The complications were identified in 12 (23.1%) cases, 5 of which involved loss of reduction. All of these 5 cases were lacking of initial medial column support and 4 of which were type C2.3 AO-Classification. CONCLUSION: The data show that the combination of angular stability with the possibility of variable polyaxial screw direction is a good concept for reduction and fixation of displaced proximal humeral fractures, but anatomical reduction and medial support remain important preconditions for a good outcome. However, a significantly lower rate of complications or better clinical outcome than that reported in the literature could not be found.

Incomplete bundle-branch block and ST-segment elevation: syndrome associated with sustained monomorphic ventricular tachycardia in patients with apparently normal heart.

This paper reports on three cases of patients with an apparently normal heart admitted for sustained monomorphic ventricular tachycardia. The only abnormal finding showed in the electrocardiogram (ECG) in sinus rhythm that exhibited an entity associated with incomplete right bundle-branch block and persistent ST-segment elevation. The ECG entity was variable and disappeared transiently. Spontaneous ventricular tachycardia in one patient was inducible by programmed stimulation. There was no underlying heart disease. The origin of the ventricular tachycardia in one patient was located by pace mapping in the left ventricle at the left ventricular basal septum. The follow-up (from 6 months up to 6 years) demonstrated a good prognosis. This particular ECG entity associated with monomorphic ventricular tachycardia could have been missed because of the variations in the ECG in sinus rhythm and was associated with a favorable prognosis.

[Tachycardia and ensuing electrosystole]. / Tachycardies et entraînement électrosystolique.

The benign or severe nature of a ventricular extrasystole depends on a number of parameters which involve the pathophysiological mechanism of the extrasystole: re-entry, exaggerated normal or abnormal automatism and therefore the presence or absence of an underlying cardiac disease. The prognosis depends directly on the morphology, the number and the characteristics of the arrhythmia. Various investigations are often necessary to evaluate this prognosis, including 24 hour Holter monitoring, stress test and electrophysiological investigations.

[Syncope and fainting in patients with a cardiac pacemaker]. / Syncopes et malaises chez le porteur de stimulateur cardiaque.

When a patient with a cardiac pacemaker presents with syncope or faintness, one's first thought should be failure of the pacemaker. If the abnormality is not apparent, the patient needs a full cardiological investigation, including "active" electrocardiographic recordings: magnet test, programming, or even Holter monitor should be performed in order to exclude the responsibility of the pacemaker. Modern pacemakers can fail and cause syncope, especially if they have been inadequately or incorrectly regulated. The so-called physiological (double chamber) pacemakers can induce dangerous arrhythmias. Programming of the pacemaker can avoid further operation and can relieve the syncope: acceleration to prevent twisting of the apex, increase in the power of the impulses to eliminate the defects in stimulation due, for example, to a rise in the threshold. The syncope may also be caused by an extracardiac cause: associated pathology or useless implantation; the simplicity of implantation techniques sometimes means that pacemakers are implanted in inappropriate cases.

[Physiologic stimulation: the future or a passing phase?]. / Stimulation physiologique: est-ce l'avenir ou une mode passagère?

Pacing techniques achieving normal AV synchrony are termed "physiologic". All rely on an atrial pacing or/and pacing system usually coupled with ventricular pacing. The major advantage is haemodynamic, usually related to the varying ventricular pacing rate obtained with atrial sensing systems only. Problems related to the more complex implantation technique, the cost of this system, its limited lifetime, more frequent iatrogenic complications and in particular the risk of reentry electronic "tachycardias" with the presently available models including an atrial sensing function, should limit the use of these devices to patients who really need AV synchrony if the implantation is technically possible, i.e., in our opinion, 10 to 15% of patients.

[A chronological linkage technic of records and use of the obtained information. Application to the functional control of cardiac stimulators]. / Une technique de chainage chronologique de dossiers et exploitation du fichier obtenu: Application au controle du fonctionnement des stimulateurs cardiaques.

The application of information processing to the study of the evolution of the patient's state requires the constituting of a file which contains the values of different items as functions of time. There are many methods for doing this and most of them appeal to the construction of a complex database. The technique presented in the paper paper tries at first to constitute, for each patient, some records, of which every one corresponds to a determined "operation' (the term "operation' is taken in the wide sense; example: consultation, surgical intervention,...) then to link them according to the chronological order. It has the advantage of being easy so that it may be used even on minicomputers. Furthermore, the exploitation of the resultant data file is very easy. This method is well suited to problems such as the examination of the longitudinal investigations, the treatment of records of the patients who went through several operations, etc. The application presented here is the checking of the functioning of pacemakers. We wrote on a minicomputer MITRA 15/125 transferable general program (using FORTRAN IV exclusively), which allows one to carry out the linking and to exploit the resultant file. It is so designed that the addition of new procedures involved in new applications may be very easy.

[French evaluation of cardiac stimulation]. / Bilan francais de la stimulation cardiaque.

A national enquiry into the problems related to definitive cardiac pacemakers, carried out in 1975, has yielded certain essential findings: the number of first-time implantations of pacemakers has been increasing by about 20% per annum; 92% of electrodes are currently implanted by an endocavitary technique, thoracotomy having now practically been abandoned; 90% of pacemakers implanted in 1975 were threshold models, inhibited by a QRS complex; the indications have become progressively wider, and are essentially related with the various forms of bradycardia, most frequently those due to atrio--ventricular block. In 1976, we have now reached a figure of about 200 new implantations of pacemakers per million inhabitants; those using lithium are increasingly superceding the mercury and isotope models.