Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Inflammation ; 38(6): 2026-35, 2015 Dec.
Article in English | MEDLINE | ID: mdl-25962375

ABSTRACT

Acute respiratory distress syndrome (ARDS) is the most severe lung inflammatory manifestation and has no effective therapy nowadays. Sepsis is one of the main illnesses among ARDS causes. The use of fluid resuscitation is an important treatment for sepsis, but positive fluid balance may induce pulmonary injury. As an alternative, fluid resuscitation with hypertonic saline ((HS) NaCl 7.5%) has been described as a promising therapeutical agent in sepsis-induced ARDS by the diminished amount of fluid necessary. Thus, we evaluated the effect of hypertonic saline in the treatment of LPS-induced ARDS. We found that hypertonic saline (NaCl 7.5%) treatment in rat model of LPS-induced ARDS avoided pulmonary function worsening and inhibited type I collagen deposition. In addition, hypertonic saline prevented pulmonary injury by decreasing metalloproteinase 9 (MMP-9) activity in tissue. Focal adhesion kinase (FAK) activation was reduced in HS group as well as neutrophil infiltration, NOS2 expression and NO content. Our study shows that fluid resuscitation with hypertonic saline decreases the progression of LPS-induced ARDS due to inhibition of pulmonary remodeling that is observed when regular saline is used.


Subject(s)
Acute Lung Injury/prevention & control , Airway Remodeling , Fluid Therapy/methods , Lipopolysaccharides , Lung , Respiratory Distress Syndrome/therapy , Saline Solution, Hypertonic/administration & dosage , Acute Lung Injury/chemically induced , Acute Lung Injury/metabolism , Acute Lung Injury/physiopathology , Airway Resistance , Animals , Collagen Type I/metabolism , Disease Models, Animal , Focal Adhesion Kinase 1/metabolism , Lung/metabolism , Lung/pathology , Lung/physiopathology , Male , Matrix Metalloproteinase 9/metabolism , Neutrophil Infiltration , Nitric Oxide/metabolism , Nitric Oxide Synthase Type II/metabolism , Pulmonary Edema/chemically induced , Pulmonary Edema/prevention & control , Rats, Wistar , Respiratory Distress Syndrome/chemically induced , Respiratory Distress Syndrome/metabolism , Respiratory Distress Syndrome/physiopathology , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...