ABSTRACT
The aim of this study was to examine the lysozyme activity in saliva of pharmaceutic industry workers in whom pathologic changes in the oral cavity were previously diagnosed. The study was carried out in the Pharmaceutic Plant "Polfa" in Stargard Gdanski at the departments of sulphonamides, acetylsalicylic acid and various syntheses. The study comprised 94 workers from whom resting saliva samples were collected 2-3 hours after breakfast. The lysozyme activity was determined using the modified Litwack method, while proteins were examined using the Lawry method. Our examinations have demonstrated a higher enzyme activity in pharmaceutic industry workers as compared to the control group. The highest lysozyme activity was recorded at the sulphonamides department.
Subject(s)
Clinical Enzyme Tests , Drug Industry , Mouth Diseases/diagnosis , Muramidase/metabolism , Occupational Diseases/diagnosis , Saliva/enzymology , Sulfonamides/toxicity , Adolescent , Adult , Age Factors , Enzyme Activation/drug effects , Female , Humans , Male , Middle Aged , Mouth Diseases/chemically induced , Mouth Diseases/enzymology , Muramidase/analysis , Occupational Diseases/chemically induced , Occupational Diseases/enzymology , Poland , Sulfonamides/chemical synthesisABSTRACT
The studies involved 94 workers of one of pharmaceutical plants producing sulphonamides, aspirin, and psychotropic drugs. The subjects exhibited higher rate of stomatopathies, as compared to controls. The greatest exposure to hazards occurred at the Division of Sulphonamides where numerous cases of leukoplakia and oral mucosa inflammation, probably of allergic origin, were noted. The need for a better dental care for workers, especially within adaptation to environmental conditions was pointed out.
