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Nutrients ; 12(6)2020 Jun 01.
Article in English | MEDLINE | ID: mdl-32492905

ABSTRACT

This study aimed to evaluate the protective role of ground raspberry seeds (RBS) as a source of polyphenols and essential fatty acids on blood plasma enzymatic antioxidant status, lipid profile, and endothelium-intact vasodilation during physiological and pathological conditions. Young normotensive Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) at ten weeks of age were fed with either a control diet or were supplemented with added 7% RBS for six weeks (n = 6). The main component of RBS was dietary fiber (64%) and the main polyphenols were ellagitannins (1.2%) and flavan-3-ols (0.45%). Irrespective of the rat model, ground RBS decreased liver enzyme aspartate aminotransferase (0.9-fold) and hydrogen peroxide scavenging capacity (Catalase, 0.9-fold). In supplemented SHRs, preincubation with inducible nitric oxide synthase (iNOS) inhibitor 1400W, nonselective cyclooxygenase (COX) inhibitor indomethacin, selective COX-2 inhibitor NS-398, prostacyclin (PGI2) synthesis inhibitor tranylcypromine (TCP), thromboxane receptor (TP) antagonist SQ-29548, thromboxane synthesis inhibitor furegrelate, and 20-HETE synthesis inhibitor HET0016 induced the same relaxant response to acetylcholine as in the nonsupplemented control group. In supplemented WKYs, atherogenic index was decreased (0.8-fold), while iNOS and COX-2-derived PGI2 increased acetylcholine-induced vasodilation. These effects of ground RBS may constitute a potential mechanism for preventing cardiovascular diseases.


Subject(s)
Cardiovascular Diseases/prevention & control , Dietary Fiber/administration & dosage , Dietary Supplements , Flavonoids/administration & dosage , Hydrolyzable Tannins/administration & dosage , Hypertension/metabolism , Liver/metabolism , Rubus , Acetylcholine , Animals , Aspartate Aminotransferases/metabolism , Atherosclerosis/prevention & control , Cardiovascular Diseases/etiology , Catalase/metabolism , Cyclooxygenase 2/metabolism , Disease Models, Animal , Epoprostenol/metabolism , Hypertension/complications , Male , Nitric Oxide Synthase Type II/metabolism , Rats, Inbred SHR , Rats, Inbred WKY , Rubus/chemistry , Vasodilation
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