[Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor]. / Sdvigi fraktsii lipidov krovi pri korrektsii arterial'no'i gipertenzii prazozinom i trazikorom.

The paper deals with the study into the benefits of prazosin and trasicor used in arterial hypertension. Their effects on the blood lipid composition were evaluated. With prazosin, the steady antihypertensive effect was reached in 81.0%, whereas with trasicor, it was attained in 46%. When prazosin was given, total cholesterol and triglycerides were statistically significantly decreased by 6.8 and 14.8%, respectively, while high density lipoproteins was increased by 9.1%. When trasicor was administered, no changes were observed in the spectrum of serum lipids. Thus, prazosin is effective in correcting two major risk factors for coronary heart disease, namely arterial hypertension and hyperlipoproteinemia, thereby reducing a risk for coronary heart disease.

[Composition, level and ratio of low density protein fraction and very low density lipoprotein subfraction in the serum of patients with chronic kidney insufficiency]. / Sostav, kontsentratsiia i velichina fraktsii lipoproteidov nizkoi plotnosti i subfraktsii lipoproteidov ochen' nizkoi plotnosti syvorotki krovi bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu.

Low density lipoproteins (LDL) and four subfractions of very low density lipoprotein (VLDL) were isolated by means of density gradient preparative ultracentrifugation from blood serum of patients with chronic renal failure. Constituents of the fractions were analyzed and physico-chemical characteristics of the lipoprotein particles were studied. These data showed that there are pronounced changes in the composition of VLDL subfractions containing small particles, thus suggesting the impaired catabolism of the particles in blood.