ABSTRACT
AIMS: We examined the characteristics of upper gastrointestinal disorders induced by non-steroidal anti-inflammatory drugs (NSAIDs). METHODOLOGY: The questionnaire investigation was performed over a five year period. RESULTS: A study was performed on 354 patients (161 men and 193 women with mean ages of 66.0 and 70.7 years, respectively) who developed NSAIDs associated upper GI disorders: 21 patients had AGML, 212 had gastric ulcer, 63 had duodenal ulcer, 17 had gastroduodenal ulcers and 41 other cases. About 75 % of patients received NSAIDs for orthopedic conditions. Sixty percent of gastric disorders induced by NSAIDs affected the antrum or angulus of the stomach. The incidence of disorders of the gastric antrum was significantly higher in women than in men whilst the incidence of disorders on the gastric angulus was significantly higher in men than in women (p < 0.05). The proportion of patients with abdominal pain was significantly lower in patients over 65 years old than in those under 65 years old, and the proportion of patients with hematemesis or melena was significantly higher in patients over 80 years old than in those under 80 years old (p < 0.05). The time taken to achieve the healing stage was significantly longer in patients with greater than 3 months NSAIDs ingestion compared to patients that had received NSAIDs for less than 3 months (p < 0.05). CONCLUSIONS: Patients 65 years old and over with continuous NSAIDs use had asymptomatic ulcers, and patients 80 years old and over had hemorrhagic ulcers.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Surveys and Questionnaires , Upper Gastrointestinal Tract/drug effects , Abdominal Pain/chemically induced , Adverse Drug Reaction Reporting Systems/statistics & numerical data , Age Factors , Aged , Aged, 80 and over , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Anti-Ulcer Agents/therapeutic use , Duodenal Ulcer/chemically induced , Duodenal Ulcer/drug therapy , Female , Hematemesis/chemically induced , Humans , Male , Middle Aged , Risk Factors , Sex Factors , Stomach Ulcer/chemically induced , Stomach Ulcer/drug therapy , Time Factors , Treatment Outcome , Upper Gastrointestinal Tract/pathologySubject(s)
Catheterization , Endoscopy, Digestive System , Gallstones/therapy , Gastroenterostomy , Sphincter of Oddi , Aged , Anastomosis, Roux-en-Y , Gallstones/diagnosis , Gastrectomy , Humans , Male , Middle AgedSubject(s)
Cysts/pathology , Leiomyosarcoma/pathology , Mesentery , Peritoneal Neoplasms/pathology , Humans , Male , Middle AgedABSTRACT
We report a 30-year-old woman with pleuropericarditis, cardiac tamponade, and disseminated intravascular coagulation complicating active ulcerative colitis (UC). Other autoimmune diseases were not present. She responded to pulsed steroid therapy and anticoagulant with resolution of the complication and UC. We reviewed the literature and found 27 cases of pleuropericarditis associated with idiopathic inflammatory bowel disease (IBD). It has been reported that pleuropericarditis associated with IBD responds well to nonsteroidal antiinflammatory drugs, as well as steroids. The causes of cardiac involvement in IBD remain unclear, but the pleuropericarditis must be recognized as a potential extraintestinal manifestation of IBD.
