[A trial of using immunoglobulins of known specificity for preventing hepatitis A in regions with high epidemic activity]. / Opyt primeneniia immunoglobulinov s izvestnoi spetsifichnost'iu dlia profilaktiki gepatita A v regionakh s vysokoi aktivnost'iu épidemicheskogo protsessa.

The economic effectiveness of immunoglobulin prophylaxis (IGP), carried out among children aged 1-3 at the beginning of a seasonal rise in hepatitis A (HA) morbidity with high coefficients of protection (80-85%), was directly related to the activity of the epidemic process. Preparations with sufficiently high content of antibodies to HA virus sharply decreased the manifestation of this infection. The detection rate of the manifest forms of the infection among children covered by prophylactic measures in the foci of HA was considerably lower than among children who had not received the preparation. IGP exerted no essential influence on the dynamics of the formation of population immunity. A high share of children aged 3-4 years, seropositive to HA virus (up to 90%), validates the inadvisability of carrying out IGP in older groups of children.