Subject(s)
Fluorescent Dyes/chemical synthesis , Fluorescent Dyes/metabolism , Receptors, Histamine H3/metabolism , Cell Line , GTP-Binding Proteins/chemistry , Humans , Indicators and Reagents , Ligands , Methylation , Piperidines/chemistry , Piperidines/metabolism , Receptors, G-Protein-Coupled/chemistry , Receptors, G-Protein-Coupled/metabolism , Receptors, Histamine/chemistry , Receptors, Histamine/metabolism , Receptors, Histamine H3/chemistry , Receptors, Histamine H3/drug effects , Receptors, Histamine H4ABSTRACT
Ventilatory disturbances are the most often cause of death in neonates. The study was carried out on 80 neonates, treated in the intensive care unit. In all during the first 48 hours the following symptoms occurred: tachypnoea (above 60 per minute), cyanosis, retraction of the intercostal muscles, expiratory disturbances. Diagnosis of clinical forms of ventilatory disturbances was made basing on Hjalmarson's criteria. The results of this study imply that the most often seen form of ventilatory disturbances in neonates in the hyaline membrane disease--found in 45% of the cases. The highest mortality (75%) was seen in the meconium aspiration syndrome.
Subject(s)
Intensive Care, Neonatal/methods , Meconium Aspiration Syndrome/therapy , Respiration, Artificial/methods , Respiratory Distress Syndrome, Newborn/therapy , Humans , Hyaline Membrane Disease/diagnostic imaging , Hyaline Membrane Disease/mortality , Hyaline Membrane Disease/therapy , Infant, Newborn , Meconium Aspiration Syndrome/diagnostic imaging , Meconium Aspiration Syndrome/mortality , Radiography , Respiratory Distress Syndrome, Newborn/diagnostic imaging , Respiratory Distress Syndrome, Newborn/mortality , Sudden Infant Death/etiologyABSTRACT
Efficacy of the ceftazidime monotherapy in 120 febrile children with neoplastic diseases and granulocytopenia was compared with that of tobramycin combined with amoxycillin/ampicillin. The obtained results were similar in both types of antibiotic therapy. However, granulocytopenia was higher and septicemia was more frequent in children treated with ceftazidime. Isolated bacteria were more sensitive to ceftazidime than to tobramycin with amoxycillin/ampicillin. Both regimens were tolerated well. Despite a low number of patients in both groups, one may conclude that ceftazidime is more efficient in patients with granulocytopenia. Less adverse reactions, lower number of infections, less frequent medical procedures, elimination of the potentially toxic aminoglycosides and lower cost of therapy advocate the use of ceftazidime monotherapy.
