ABSTRACT
Fifteen patients with severe hospital infections such as postoperative pneumonia or intraabdominal sepsis were treated with ofloxacin in a dose of 400 mg once a day for 7 to 14 days (11 days at the average). The drug was administered intravenously for the first 3-5 days and then orally till the end of the treatment course. The clinical effect was observed in 14 patients (93 per cent) and the positive bacteriological effect was stated in 11 out of 13 patients (85 per cent). Before the treatment 18 microbial cultures were isolated from the patients. 94 per cent of them was susceptible to ofloxacin. The isolates of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were the most frequent. The treatment resulted in the eradication of 15 cultures (83 per cent). The adverse reactions were observed in 3 patients but only in 1 of them they were for certain due to the drug use. All the adverse reactions were insignificant or moderate and did not require the treatment discontinuation. The trials showed that ofloxacin was a highly efficient agent useful in the empirical monotherapy of patients with severe hospital infection.
Subject(s)
Anti-Infective Agents/administration & dosage , Cross Infection/drug therapy , Ofloxacin/administration & dosage , Administration, Oral , Adult , Aged , Anti-Infective Agents/adverse effects , Drug Administration Schedule , Escherichia/drug effects , Feasibility Studies , Female , Humans , Infusions, Intravenous , Male , Microbial Sensitivity Tests , Middle Aged , Ofloxacin/adverse effects , Pseudomonas/drug effects , Staphylococcus aureus/drug effects , Treatment OutcomeABSTRACT
The comparative study of the fibronectin-binding capacity of S. aureus and S. epidermidis of clinical etiology was carried out. Fibronectin binding was evaluated by original methods: the indirect hemagglutination test and the passive coagglutination test. In this study the occurrence of S. epidermidis isolates, as well as their level (evaluated by the titer) of fibronectin binding, was shown to be lower than those of S. aureus isolates. Fibronectin-binding representatives of S. epidermidis lost this capacity after storage in semiliquid agar at 4 degrees C for 2 months.
