ABSTRACT
Canines historically have been proven to have great benefits in human medicine. They have a unique ability to detect volatile organic compounds, or VOCs, in several different diseases, which allows them to work efficiently as a medical alert dog or detect the presence of certain diseases in human samples. Early studies have shown efficiency in the ability of canines to detect malignant cells from primary lung tumors in the fluid and breath samples of patients. Lung cancer is the third most common cancer and is the number one cause of cancer-related deaths in the United States. Because of its commonality, The U.S. Preventive Services Task Force developed guidelines for screening high-risk individuals, which includes low-dose CT with proven efficacy. Although effective, it comes with limitations, including increased cost, concern for radiation exposure, and low compliance amongst those who are eligible for screening. Other screening methods have been studied to overcome these deficiencies, including the use of canines trained in medical scent detection. Medical scent canines may prove to be an efficient alternative form of screening to the traditional use of low-dose CT and may be a viable non-imaging screening alternative.
ABSTRACT
Celiac disease (CD) is a common chronic inflammatory disorder occurring in genetically predisposed individuals secondary to gluten ingestion. CD usually presents with gastrointestinal symptoms such as pain, bloating, flatulence, and constipation or diarrhea. However, individuals can present in a nonclassical manner with only extraintestinal symptoms. The neurological manifestations of CD include ataxia, cognitive impairment, epilepsy, headache, and neuropathy. A lifelong gluten-free diet is the current recommended treatment for CD. This review discusses the relevant neurological manifestations associated with CD and the novel therapeutics. Further research is required to get a better understanding of the underlying pathophysiology of the neurological manifestations associated with CD. Clinicians should keep CD in the differential diagnosis in individuals presenting with neurological dysfunction of unknown cause.
