[Endocrine cells of rectal epithelium in health, in nonspecific ulcerative colitis and irritable colon syndrome in the treatment with prednisolone and salofalk and in the absence of treatment]. / Endokrinnye kletki épiteliia priamoi kishki v norme, pri nespetsificheskom iazvennom kolite i sindrome razdrazhennoi kishki bez lecheniia i pri lechenii prednizolonom i salofal'kom.

The arrangement and ultrastructure of rectal intraepithelial endocrine cells in health, in nonspecific ulcerative colitis (NSUC) and in irritable colon syndrome (ICS) were studied with light and electron microscopy. An increase of the amount of these cells was registered at the initial stages of inflammation, whereas chronic and destructive states were accompanied by the cells decrease. A decrease of endocrine cells number in (NSUC) was pronounced more than in ICS. Compared to prednisolone, the treatment with salofalk produced a more positive effect on endocrine cells reproduction within the rectal lining. The endocrine cells ultrastructural changes found by the authors in ulcerative colitis and irritable colon showed similarity to those in other colon diseases.

[Antibiotics as proteolysis inhibitors in the stomach]. / Antibiotiki kak ingibitory proteoliza v zheludke.

The study was made of antibiotics action on hydrolysis of coagulated protein in gastric juice. It was established that antibiotics can produce inhibition of protein proteolysis in gastric juice. The highest antiprotease activity was reported for cephalosporins , rifampicin and penicillins, the lowest for tetracycline++. Antiprotease activity of antibiotics should be taken into consideration when defining their therapeutic effect in peptic ulcer.