ABSTRACT
Workers on exposure to epoxy resins (ER) have been shown to reveal several variants of immunogrammes of blood, expression of Fas-ligands and oxygen-dependent metabolism of phagocytes. These are as follows: the immune deficiency variant (38.1%), the autoimmune one (33.3%), the state of norm (28.6%). The blood phagocyte oxygen-dependent metabolism tends towards activation but the phagocyte functional reserve is reduced which facts suggest depression of metabolism and phagocytic defence in the organism. Identified in the study are several variants of kinetic parameters of the blood serum chemiluminescence suggesting activation/inhibition of process of free radical oxidation, strengthening/weakening of the blood antioxidant defence, which events can be regarded as early diagnostic and prognostic criteria of adverse effects of epoxy resins on the organism of those handling them. These data suggest to us an insufficient reliability of the existing maximum permissible concentration of epoxy resins in the air of the working zone and attest to the need for its reconsideration.
Subject(s)
Epoxy Resins/adverse effects , Immunity/drug effects , Occupational Exposure/adverse effects , Antigens, Surface/immunology , Fas Ligand Protein , Female , Free Radicals/metabolism , Genetic Variation , Humans , Immunity/genetics , Kinetics , Male , Membrane Glycoproteins/immunology , Middle Aged , Oxygen/metabolism , Phagocytes/immunologySubject(s)
Colitis, Ulcerative/etiology , Crohn Disease/etiology , Immune System Diseases/complications , Antibody Formation , Autoimmunity , Colitis, Ulcerative/immunology , Crohn Disease/immunology , Humans , Hypersensitivity, Immediate/immunology , Immune System Diseases/immunology , Immunity, Cellular , Intestinal Mucosa/immunologyABSTRACT
Specific complex antigen, based on human serum albumin and epichlorhydrine was proved to be useful in the diagnosis of individual hypersensitivity to the epoxide pitches and epichlorhydrine. Lymphocytes' blast transformation with 3H-timidine was proved to be the most sensitive reaction in the use of specific complex antigen during the diagnosis. The stated immune reaction can be used for the diagnosis of allergy before the clinical manifestations.