ABSTRACT
The frequency of G-6-PD deficiency in the Dar es Salaam male population is given as 18.7%. In this preliminary study, is reported a frequency of 45% in males with typhoid fever--a figure more than twice the prevalence in the general Dar es Salaam male population. Possible reasons for positive correlation between the two disease states are described.
Subject(s)
Glucosephosphate Dehydrogenase Deficiency/complications , Typhoid Fever/complications , Glucosephosphate Dehydrogenase Deficiency/epidemiology , Humans , Male , TanzaniaABSTRACT
Using both starch gel and cellulose-acetate electrophoresis is screening procedures, haemoglobin (Hb) Barts was detected in 11.08% of 325 cord blood samples from newborn Tanzanians. Red cell studies in these and in normals and a search for inclusion bodies of Hb H did not suggest alpha-thalassaemia. The mothers of these babies do not show any evidence of alpha-thalassaemia. It is suggested that the presence of Hb Barts in samples of cord blood is not due to the presence of alpha-thalassaemia in the Tanzanian population.
Subject(s)
Hemoglobins, Abnormal , Thalassemia/epidemiology , Adult , Electrophoresis, Cellulose Acetate , Electrophoresis, Starch Gel , Erythrocytes/analysis , Female , Fetal Blood/analysis , Fetal Hemoglobin/analysis , Hemoglobin H/analysis , Hemoglobins, Abnormal/analysis , Humans , Inclusion Bodies/analysis , Infant, Newborn , Osmotic Fragility , TanzaniaABSTRACT
636 normal male blood donors were studied for haemoglobin genotype and G-6-PD deficiency. The results show that of 543 subjects with AA haemoglobin, 106 (19.5%) were G-6-PD deficient and of 93 individuals with AS haemoglobin 13 (14.0%). This difference is not significant.
