[STUDY OF THE VARIABILITY OF THE CARDIAC RHYTHM IN RAILROAD EMPLOYEES, WHO SUFFER BY STOMACH ULCER AND DUODENUM, ASSOCIATED AND NONASSOCIATED WITH THE INFECTION HELICOBACTER PYLORI].

AIM OF INVESTIGATION: To estimate the Heart rate variability (HRV), by the method of daily kholterovskogo monitoring in the workers of rail transport (RT). MATERIALS AND METHODS: A total of 93 persons working in the East Siberian Railway. The main group (CG) consisted of 27 patients with gastric ulcer (GU) and duodenal ulcer (DU) contamination without Helicobacter infection. The first group of clinical comparison (GCS 1) included 36 patients with gastric ulcer and duodenal with contamination of infection H. pylori. The second group of clinical comparison (GCS 2) consisted of 30 employees VT held preventive medical examination, without contamination of Helicobacter infection is not suffering from gastric ulcer and duodenum. RESULTS: With the analysis of spectral and time characteristics HRV in Haug is revealed the explicit displacement of vegetative homeostasis with the prevalence of the sympathetic component of regulation, which is restored against the background of treatment. Meanwhile in GKS1 the indices of vegetative regulation had parasympathetic directivity, they were more close to the standard and did not change after conducting of the eradikatsionnoy therapy. CONCLUSION: The greatest unbalance of sympathetic and parasympathetic nervous system is observed in patients, workers (RT), who suffer SU and UD in the absence of the contamination of H. pylori. The use of a method of study VCR in the conditions of the absence of H. pylori infection can make it possible to form the group of risk of development SU and UD in workers RT.

[Dynamics of pulse pressure in orthostatic test: interrelationships with risk factors and involvement of the heart and vessels in elderly patients with arterial hypertension].

We studied dynamics of arterial pulse pressure (APP) during active orthostatic test (AOT) in relation to cardiac and vascular involvement in 198 elderly patients with arterial hypertension. We measured and compared parameters of hemodynamics, rate of detection of risk factors, signs of affection of the heart and vessels in subgroups with elevation of APP (n=50), lowering of APP by more than 10 mm Hg (n=50) and intermediate deviations of APP (n=98) in orthostasis. In patients with elevation of APP during AOT smoking, increased aortic stiffness, history of myocardial infarction were detected more often and risk of development of cardiovascular diseases according to SCORE system was higher than in patients with lowering of APP or absence of its dynamics. Patients with lowering of APP more than 10 mm Hg significantly more often had cerebrovascular disease appearing as history of cerebral strokes and/or transitory ischemic attacks. The conclusion was made about possible significance of orthostatic increment of APP as supplementary marker of cardiovascular risk in elderly patients with arterial hypertension.

[Cavinton forte treatment of cerebral vascular insufficiency in patients with coronary heart disease and arterial hypertension].

Using 48-h Holter monitoring of ECG and ambulatory blood pressure monitoring, 28 patients (13 men, 15 women, mean age 66.6 +/- 7.7 years) with cerebral vascular insufficiency of the I-II stage in combination with chronic coronary heart disease and essential arterial hypertension have been examined. Quantitative parameters of myocardial ischemia episodes and hypotension conditions were calculated and compared before the beginning (the first 24 h of monitoring) and during taking the daily dose of 30 mg of cavinton forte (the second 24 hours of monitoring). The distribution of ischemia and hypotension episodes in the periods of the maximal supposed effect of the drug was analyzed. Cavinton forte neither contributes to the manifestation and average frequency of myocardial ischemia episodes nor influences parameters and the character of short-term arterial hypotension episodes. The drug reduces quantity and duration of blood pressure nocturnal fall. It is concluded that initial cavinton forte treatment of cerebral vascular insufficiency in patients with chronic coronary heart disease in combination with arterial hypertension is safe when combined with hemodynamically active antihypertensive and antiischemic therapy.

[Heart rate variability in unstable angina during 'day-to-day' monitoring]. / Variabel'nost' serdechnogo ritma pri mnogodnevnom nabliudenii za techeniem nestabil'noi stenokardii.

Spectral analysis of heart rate variability was used for assessment of background autonomic activity in patients with unstable angina pectoris. There were weak linear and strong nonlinear links between autonomic activity and frequency of angina pectoris during 'day-to-day' monitoring.

[Physical exertion tolerance and the characteristics of hemodynamics in healthy persons depending on its type]. / Tolerantnost' k fizicheskoi nagruzke i osobennosti ee gemodinamicheskogo obespecheniia u zdorovykh liudei v zavisimosti ot tipa gemodinamiki.

Central hemodynamic parameters were studied in 113 normal male subjects, aged 20-59, at rest and during bicycle ergometric exercise, with the help of tetrapolar chest rheography. Capacity for physical exercise was shown to depend on both the age and the basic hemodynamic type. Subjects with hyperkinetic circulation had the greatest, and those with hypokinetic circulation, the smallest capacity for exercise. The evaluation of BP and heart rate patterns, stroke and cardiac indices, and the indicator of heart performance during bicycle ergometry suggested that cardiovascular operation was more economical in normal subjects with eukinetic or hyperkinetic circulation, hence their greater capacity for physical exercise.