ABSTRACT
The effectiveness of glycifone ointment treatment for primary multiple basal cell carcinoma of the skin was evaluated in 28 patients. 27 cases were cured following one or two courses the duration of which was determined by the number of foci, pattern of tumor and its total surface area.
Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Glyceryl Ethers/therapeutic use , Skin Neoplasms/drug therapy , Administration, Cutaneous , Drug Administration Schedule , Female , Humans , Male , Treatment OutcomeABSTRACT
The ratios between dermatoglyphic patterns of different types were studied in males and females with and without hereditary diseases of the skin. It was found that ridge patterns of fingers are determined by special polygenes. Patients with monogenic dermatoses (X-linked ichthyosis and autosomal recessive ichthyosiform erythroderma) exhibited a suppressed formation of the loop pattern compared to control subjects.
Subject(s)
Ichthyosiform Erythroderma, Congenital/genetics , Ichthyosis, X-Linked/genetics , Dermatoglyphics , Female , Genotype , Humans , Ichthyosiform Erythroderma, Congenital/pathology , Ichthyosis, X-Linked/pathology , MaleABSTRACT
Electron-microscopic examinations of the epidermis in 11 patients suffering from xeroderma with autosomal dominant and X-recessive inheritance have revealed changes in the basal membrane, scarce pinocytotic vesicles near the basal membrane, inter- and intracellular edemas in the epidermis, a decrease of the desmosomal contacts and an increased number of microvilli on the epidermocytes of the basal and prickle-cell layers, condensation of the nucleoplasm, reduced counts of organelles and condensation of the epidermocyte tonofilaments, hyperkeratosis, and an elevated count of the desmosomes in the horny layer in both forms of ichthyosis. Autosomal dominant ichthyosis is characterized by the presence of just few intact, or by complete absence of keratohyalin granules in the granular layer. The detected ultrastructural signs may be used in the differential diagnosis between various ichthyosis forms and may contribute to deciphering the pathogenetic mechanisms of impairment of keratinization in this hereditary dermatosis.
