1.
Zh Mikrobiol Epidemiol Immunobiol
; (3): 78-82, 1984 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-6730810
ABSTRACT
The possibility of the oral use of heated corpuscular vaccine prepared from S. minnesota mutant R 595 (chemotype Re) for protection against Pseudomonas aeruginosa has been studied. Oral immunization in 3 doses, each containing 10(9) cells of the vaccine strain, has been shown to protect mice from death after the intravenous injection of P. aeruginosa culture in a dose of 5 LD50 and induce a rise in the titers of antibodies to Re-glycolipid (Re-hemagglutinins). After multiple oral administration Re-vaccine shows low acute and chronic toxicity and induces local and systemic immunological transformation.
Subject(s)
Bacterial Vaccines/immunology , Mutation , Salmonella/immunology , Administration, Oral , Animals , Antibodies, Bacterial/analysis , Bacterial Vaccines/administration & dosage , Bacterial Vaccines/toxicity , Dose-Response Relationship, Immunologic , Drug Evaluation, Preclinical , Immunization , Lethal Dose 50 , Mice , Pseudomonas Infections/prevention & control , Time Factors
2.
Zh Mikrobiol Epidemiol Immunobiol
; (12): 60-5, 1980 Dec.
Article
in Russian
| MEDLINE
| ID: mdl-7223192