ABSTRACT
In this work we for the first time revealed on clinical - genetic material association between hereditary disturbances of cardiac conduction and polymorphism of 2-adrenergic receptor gene.
Subject(s)
Arrhythmias, Cardiac/genetics , Polymorphism, Genetic , Receptors, Adrenergic, beta-2/genetics , Female , Genetic Predisposition to Disease , Humans , Male , Middle AgedABSTRACT
In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome (SSNS) ADRA2B and eNOS genes polymorphisms. We have established predominance of homozygote genotype of more rare DD allele in patients with SSNS (28%) compared with subjects of control group (8.99%). We have found predominance of heterozygote genotype 4a/4b in patients with SSNS compared with subjects of control group (41.8 and 25.39%, respectively). The data obtained allow to suggest that eNOS gene polymorphism might be associated with SSNS.
Subject(s)
Nitric Oxide Synthase Type III/genetics , Polymorphism, Genetic , Receptors, Adrenergic, alpha-2/genetics , Sick Sinus Syndrome/genetics , Sinoatrial Node/abnormalities , Adult , Alleles , Electrocardiography , Female , Genetic Predisposition to Disease , Homozygote , Humans , Male , Middle Aged , Sick Sinus Syndrome/diagnosisABSTRACT
In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome and connexin 40 gene polymorphism. We have revealed that heterozygous variant of connexin 40 gene variant is more frequent among patients with sick sinus node syndrome and their healthy relatives than in persons of control group.
