Subject(s)
Wounds and Injuries/immunology , Acute Disease , Antibody Formation , Antibody-Producing Cells/immunology , B-Lymphocytes/immunology , Cell Movement , Humans , Immune Tolerance , Immunity, Cellular , Macrophages/immunology , T-Lymphocytes/immunology , Time Factors , Wounds and Injuries/pathologyABSTRACT
Experiments on mice have shown that severe mechanical trauma brings about phasic changes in the kinetics of hemopoietic stem cell migration. Within the first four days after the trauma the migration of stem cells gets intensified and returns to normal by day 8. This reaction is regarded to be a defence one, since it guarantees the function of the most important component of immunity, namely the organs where stem cells differentiate as T and B lymphocytes.
Subject(s)
Crush Syndrome/physiopathology , Hematopoietic Stem Cells/physiology , Shock, Traumatic/physiopathology , Animals , Bone Marrow Cells , Cell Movement/radiation effects , Colony-Forming Units Assay , Female , Hematopoietic Stem Cells/radiation effects , Kinetics , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Time FactorsSubject(s)
Shock, Traumatic/etiology , Adrenal Glands/physiopathology , Animals , Blood Circulation , Brain/physiopathology , Energy Metabolism , Hemorrhage/physiopathology , Hypotension/physiopathology , Hypothalamo-Hypophyseal System/physiopathology , Nervous System/physiopathology , Research , Shock, Hemorrhagic/etiology , Shock, Hemorrhagic/physiopathology , Shock, Hemorrhagic/therapy , Shock, Traumatic/physiopathology , Shock, Traumatic/therapy , Stress, Physiological/physiopathologySubject(s)
Glucose/therapeutic use , Hypoxia/drug therapy , Nucleotides/therapeutic use , Shock/drug therapy , Adenine Nucleotides/therapeutic use , Animals , Cytochrome c Group/therapeutic use , Dogs , Guanine Nucleotides/therapeutic use , Humans , Hypoxia/etiology , Hypoxia/metabolism , NAD/therapeutic use , Nicotinic Acids/therapeutic use , Shock/complications , Shock/metabolism , Succinates/therapeutic use , Thiourea/analogs & derivatives , Thiourea/therapeutic useSubject(s)
11-Hydroxycorticosteroids/metabolism , Adrenal Cortex/metabolism , Hemorrhage/metabolism , Animals , Dogs , Female , MaleABSTRACT
The authors studied the activity of acid phosphatase (AP), lactic dehydrogenase (LDH), aspartic and alanine-aminotranspherases (AST and ALT) in the serum of rats with intact and removed adrenal glands after a severe multifocal trauma induced according to Noble-Collip (300 rpt of the drum with the rotation speed of 37 rpt/min). Adrenalectomy showed practically no influence on the dynamics of the LDH and AP activity. An increase in the activity of the AST and especially of the ALT in the serum of adrenalectomized rats after the trauma was considerably less than in the animals with the intact adrenal glands.