ABSTRACT
The immunoregulating effect of phenibut has been demonstrated on the model of immune stress caused by the injection of lipopolysaccharide from Pseudomonas aeruginosa. The degree of expression of the specific (in a delayed-type hypersensitivity reaction and passive hemagglutination) and nonspecific (phagocytic activity of neutrophils) links of immunomodulation was studied. The formation of lipopolysaccharide (LPS) induced immune stress is characterized by the increase of the indicated parameters of immunity. It is found that phenibut (under intraabdominal injection of 25 mg/kg within 5 days) removes the manifestations of hyperreactivity of the cellular link of immunity, and also restores the amount of phagocytic cells, which is evidence of the immunomodulating properties of the drug under conditions of hyperimmunization.
Subject(s)
Immune System/drug effects , Immunologic Factors/pharmacology , Lipopolysaccharides/pharmacology , Stress, Physiological/drug effects , gamma-Aminobutyric Acid/analogs & derivatives , Animals , Female , Hemagglutination/drug effects , Hypersensitivity, Delayed/drug therapy , Hypersensitivity, Delayed/immunology , Immunity, Cellular/drug effects , Immunity, Humoral/drug effects , Immunologic Factors/therapeutic use , Male , Neutrophils/drug effects , Neutrophils/immunology , Phagocytosis/drug effects , Pseudomonas aeruginosa , Rats , Rats, Wistar , gamma-Aminobutyric Acid/pharmacology , gamma-Aminobutyric Acid/therapeutic useABSTRACT
Experiments on CBA mice with model immunodepression induced by cyclophosphamide showed that phenibut (25 mg/kg) and gammoxin (25 mg/kg) recover both cellular and humoral immunoreactivity and restore lymphoproliferative processes in immunocompetent organs, which is evidence for pronounced immunocorrecting properties of these drugs. A comparative analysis of the immunomodulating activity of phenibut and gammoxin showed that the latter drug predominantly affects the process of immunocompetent cell maturation (growth in mass and cellularity of thymus and spleen--the central immunocompetent organs), while phenibut mostly influences the realization of the final reaction of the primary anti-erythrocyte immune response (significant correction of local infiltration delayed-type hypersensitivity reaction and antibody formation). This difference can be related to the fact that the drugs influence GABA receptors of different types, whereby gammoxin acts on these receptors in immunocompetent organs and phenibut acts on the receptors in lymphocytes.
