Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules.

Enantioselective syntheses of the potent antifungal agent (-)-jesterone, its hydroxy epimer, and a dimeric quinone epoxide derivative are reported. The synthesis involves diastereoselective epoxidation of a chiral quinone monoketal derivative and regio- and stereoselective reduction of a quinone epoxide intermediate.

Characterization and Antimicrobial Activity of Erbium(III) Complexes of C-3 Substituted 2-hydroxy-1,4-naphthalenedione-1-oxime Derivatives.

Erbium(III) complexes of 2-hydroxy-l,4-naphthalenedione-1-oxime and its C-3 substituted derivatives are synthesized and characterized by elemental analysis, thermogravimetric analysis, infrared spectroscopy, magnetic susceptibility measurements 2-hydroxy-1,4-naphthalenedione-1-oxime derivatives are analysed using (1)H and (13)C NMR spectroscopy. The molecular composition of the synthesized complexes is found to be [ML(3)(H(2)O)(2)]. The antimicrobial activity of these complexes is determined by well diffusion method against the target microorganisms- Staphylococcus aureus, Xanthomonas campestris, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antimicrobial activities of 2- hydroxy-1,4-naphthalenedione-1-oximes and their complexes are compared. It is observed that 2-hydroxy-1,4-naphthalenedione-l-oximes exhibit higher antifungal activity as compared to antibacterial activity. These activities are reduced upon complexation of these oximes with Erbium.

A selenide linker for "traceless" solid-phase organic synthesis.

4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.

C-3 Substituted Lawsonemonoximates of Holmium(III): Synthesis, Characterization, and Antimicrobial Activity.

A series of five new metal complexes of Ho(III) with C-3 substituted derivatives of lawsonemonexime (2-hydroxy-1,4-naphthalenediene-1-oxime) were synthesized. The compounds were characterized by melting point, elemental analysis, IR spectroscopy and magnetic susceptibility. The antimicrobial activity of the compounds were determined by disk diffusion method and broth micro-dilution techniques using Mueller Hinton medium against the following organisms: S. aureus ATCC 6538P, Klebsiella pneumoniae, NCTC 418, Pseudomonas aeruginosa ATCC 27833, Salmonella typhimurium ATCC 23564, E. coli U 1777, E. coli HB101, Proteus morganii NCIM 2860, Providencia stuartii NCIM 2799 and Acinetobacter baumannii U 24. The chelates of Ho(III) with lawsonemonoxime and Ho(III) with 3-bromolawsonemonoxime showed a variable antimicrobial activity against all organisms tested except Pseudomonas and Klebsiella spp. S. aureus was found more sensitive to all ligands and chelates tested; but the MIC values of chelates were considerably less; thus having more antimicrobial effect.

Amebic pericarditis following ruptured right liver lobe abscess.

We present an unusual case of suppurative pericarditis following rupture of a solitary right lobe amebic liver abscess. The condition was treated successfully by drainage of the liver abscess alone.

Ileo-caeco-colic intussusception due to extensive benign lymphoid hyperplasia of the ileo-caecal region (a case report).

An unusual case of extensive benign lymphoid hyperplasia of the ileo-caecal region causing ileo-caeco-colic intussusception is presented here, with a review of relevant literature. The diagnosis of intussusception was reached with the help of an abdominal ultrasound and barium enema. Histopathology of the resected specimen, revealed lymphoid hyperplasia.

Immunological studies on seminal plasma proteins of the Indian buffalo and cattle.

Seminal plasma proteins of the Indian buffalo and cattle were immunologically investigated using rabbit antibuffalo seminal plasma serum, rabbit anticattle seminal plasma serum (unabsorbed and absorbed), gel diffusion, and immunoelectrophoretic analysis. At least 9-12 and 7-10 different proteins, respectively, were present in the seminal plasma of the buffalo and cattle. Albumin and IgG were identified in both the species. At least 4-6 seminal plasma proteins of the buffalo and cattle were antigenically similar to their blood serum proteins. Using absorbed rabbit antibuffalo seminal plasma serum and rabbit anticattle seminal plasma serum, at least 6-7 and 5-6 seminal plasma specific proteins, respectively, were observed in the buffalo and cattle seminal plasma. Antigenically these proteins were different from the blood serum proteins of these two species. The origin and biological significance of seminal plasma proteins are discussed.

Seminal plasma immunoglobulins of the Indian buffalo.

Seminal plasma immunoglobulins of normospermic fertile Indian buffalo bulls were investigated using rabbit antibuffalo immunoglobulin (polyvalent) serum, rabbit antibuffalo IgG and IgM serums, gel diffusion, and immunoelectrophoretic analysis. Immunoglobulin G was the predominant immunoglobulin in the seminal plasma of the buffalo. Strong antigenic cross reactions were observed between the seminal plasma IgG molecules of the buffalo and cattle, indicating the structural homology of seminal plasma IgG of these two species. These observations are in accordance with the close taxonomic and phylogenetic relationship between buffalo and cattle in the evolution of ruminant species.

Fetal specific serum proteins of the Indian buffalo.

Fetal specific serum proteins of the Indian buffalo were investigated using rabbit antibuffalo fetal serum, absorbed with lyophilised adult buffalo serum, and subjected to gel diffusion and immunoelectrophoretic analysis. AFP was found to be the major fetal specific serum protein of the Indian buffalo. A close antigenic relationship between the fetal specific serum proteins of the buffalo, sheep and goat and a distant relationship between these proteins of ruminants and man was found by immunological cross reaction studies.