ABSTRACT
A comparative study of the effectiveness of the early rehabilitative treatment of post-stroke patients in a specialized hospital located in a medium-altitude mountainous area and in an outpatient clinic in the city of Bishkek (low altitude) was carried out. A more noticeable positive dynamics of the disturbed motor function and quality of life was documented in the patients treated in the mid-altitude in-patient hospital.
Subject(s)
Altitude , Health Resorts , Physical Therapy Modalities , Stroke Rehabilitation , Combined Modality Therapy , Humans , Kyrgyzstan , Quality of Life , Severity of Illness Index , Treatment OutcomeABSTRACT
Subcortical arteriosclerotic encephalopathy (SAE) is a chronic progressive form of brain blood supply deficiency. Risk factors for SAE development were studied in 65 patients (42 men and 23 women, mean age 60.5 +/- 7.5 years). A control group included 31 patients (17 men and 14 women, mean age 59.3 +/- 7.4 years) with isolated clinically meaningful lacunar infarcts. A main risk factor for SAE was arterial hypertension (AH) emerging in 98.5% of the patients, which, according to twenty-four hour monitoring, differed significantly from that in the patients with isolated lacunar infarcts. In SAE, diastolic pressure was higher, systolic AP variability was detected more frequent, physiological AP decreased rarely in the nighttime, but AP fell down extremely more often. A frequency of other risk factors (ischemic disease, atrial fibrillation, diabetes mellitus, smoking, elevation of hematocrit, fibrinogen and platelet aggregation) did not differ significantly comparing to isolated lacunar infarcts. Hypercholesterolemia was detected more frequently in the controls than in the SAE patients. The study revealed that AP with hemodynamic features, pathogenetically crucial for development of disseminated arteriolosclerosis in small brain arteries and arterioles as well as for diffuse white matter damage in brain hemispheres characteristic for SAE, is a main risk factor for SAE.
Subject(s)
Dementia, Vascular/etiology , Hypertension/complications , Diabetes Complications , Female , Humans , Hypercholesterolemia/complications , Male , Middle Aged , Myocardial Ischemia/complications , Risk Factors , Smoking/adverse effectsABSTRACT
HLA antigens were studied in 121 patients with dissemination sclerosis and 50 patients with retrobulbar neuritis. In both diseases the rate of antigen B7 distribution was increased and that of antigens B17, B40 decreased. The data suggest that both diseases have common pathogenic links.
